| Author | Matta Cahacho, Nubia Estela | |
| Author | Nogueira, Ricardo dos Santos | |
| Author | Franco, Antonia Maria Ramos | |
| Author | Souza, Ilner de Souza e | |
| Author | Mattos, Marise da Silva | |
| Author | Oliveira Neto, Manoel Paes de | |
| Author | Coutinho, Sergio Gomes | |
| Author | Leon, Leonor Laura Pinto | |
| Author | Cruz, Alda Maria da | |
| Access date | 2018-07-17T13:53:48Z | |
| Available date | 2018-07-17T13:53:48Z | |
| Document date | 2009 | |
| Citation | MATTA CAHACHO, Nubia Estela et al. Leishmania (Viannia) guyanensis induces low immunologic responsiveness in Leishmaniasis patients from an endemic area of the brazilian Amazon highland. The American Journal of Tropical Medicine and Hygiene, v. 80, n. 3, p. 339-344, Mar. 2009. | |
| ISSN | 0002-9637 | |
| URI | https://www.arca.fiocruz.br/handle/icict/27563 | |
| Description | Produção científica do Laboratório de Bioquímica de Tripanossomatídeos. | pt_BR |
| Description | Produção científica do Laboratório de Imunoparasitologia. | pt_BR |
| Language | eng | en_US |
| Publisher | American Society of Tropical Medicine and Hygiene | |
| Rights | restricted access | |
| Subject in Portuguese | Leishmania (Viannia) guyanensis | pt_BR |
| Subject in Portuguese | Áreas endêmicas | pt_BR |
| Subject in Portuguese | Baixa responsividade imunológica | pt_BR |
| Subject in Portuguese | Amazônia Brasileira | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Title | Leishmania (Viannia) guyanensis induces low immunologic responsiveness in Leishmaniasis patients from an endemic area of the brazilian Amazon highland | en_US |
| Type | Article | |
| DOI | 10.4269/ajtmh.2009.80.339 | |
| Abstract | Cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoproliferative responses (LPRs) to Leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lymphocytes, mainly TCD4⁺. High and low interferon (IFN)-γ producers were observed. TNF-α, interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to L. braziliensis patients. CL caused by L. braziliensis presented positive LPRs and higher IFN-γ production but undetectable IL-5. L. guyanensis seems to induce a down-regulation of the immune system compared with L. braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Instituto Nacional de Pesquisas da Amazônia. Departamento de Ciências da Saúde. Divisão de Parasitologia I. Laboratório de Leishmanioses e Doença de Chagas. Manus, AM, Brasil. | |
| Affilliation | Universidade Federal do Amazonas. Faculdade de Ciências da Saúde. Departamento de Saúde Coletiva. Manaus, AM, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | |
| Subject | Leishmania (Viannia) guyanensis | en_US |
| Subject | Leishmaniasis | en_US |
| Subject | Endemic Area | en_US |
| Subject | Brazilian Amazon | en_US |
| Subject | Low Immunologic Responsiveness | en_US |
| e-ISSN | 1476-1645 | |
