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2030-01-01
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- ENSP - Artigos de Periódicos [2283]
- IOC - Artigos de Periódicos [12422]
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THE ACCURACY OF ANTI-HUMAN HERPESVIRUS 6 IGM DETECTION IN CHILDREN WITH RECENT PRIMARY INFECTION
Author
Affilliation
Fundação Municipal de Saúde de Niterói. Policlínica Comunitária do Largo da Batalha. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Medicina Clínica. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
Health Protection Agency. Colindale, London, UK.
Health Protection Agency. Colindale, London, UK.
Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Medicina Clínica. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Medicina Clínica. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
Health Protection Agency. Colindale, London, UK.
Health Protection Agency. Colindale, London, UK.
Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Medicina Clínica. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
Abstract
Human herpesvirus 6 (HHV-6) has been shown to infect almost all children by 4 years of age. Even with a typical clinical presentation, HHV-6 infection is misdiagnosed frequently as measles or rubella. The aim of this study was to assess the accuracy of the IgM test for detection of recent primary HHV-6 infection. The study was conducted between January, 1998 and December, 2006 at primary health care units in Niterói, Rio de Janeiro, Brazil. Sera from 185 children, in whom measles, rubella, dengue fever and parvovirus B19 infections were excluded, were studied for anti-HHV-6 IgG and IgM antibodies using an indirect immunofluorescence test. Seventy-one (38.4%) of the children had evidence of primary HHV-6 infection. Taking the IgG avidity test as the "gold standard", the following results for IgM were obtained-sensitivity: 76.1%; specificity: 87.5%; accuracy: 82.4%. This study confirmed the low accuracy of IgM detection for the diagnosis of primary HHV-6 infection.
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