Canine vector-borne diseases (CVBDs) comprise a group of globally distributed and rapidly spreading illnesses that are caused by a range of pathogens transmitted by arthropods including ticks, fleas, mosquitoes and phlebotomine sandflies. In addition to their veterinary importance, some CVBD-causing pathogens are of major zoonotic concern. Recent studies using sophisticated and advanced methodologies and technologies have provided new insights into the epidemiology of many CVBDs. This review is the first of two articles and focuses on the zoonotic relevance of CVBDs, the significance of co-infection and the role of infected but clinically healthy dogs in spreading different pathogens among human and canine populations.