Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28017
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dc.contributor.authorCooper, Philip J.
dc.contributor.authorChico, Martha E.
dc.contributor.authorVaca, Maritza G.
dc.contributor.authorSandoval, Carlos A.
dc.contributor.authorLoor, Sofia
dc.contributor.authorAmorim, Leila Denise Alves Ferreira
dc.contributor.authorRodrigues, Laura Cunha
dc.contributor.authorBarreto, Maurício Lima
dc.contributor.authorStrachan, David P.
dc.date.accessioned2018-08-08T16:56:20Z
dc.date.available2018-08-08T16:56:20Z
dc.date.issued2018
dc.identifier.citationCOOPER, Philip J. et al. Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age. American Journal of Respiratory and Critical Care Medicine, v. 197, n. 3, p. 364-372, 2018.
dc.identifier.issn1073-449X
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/28017
dc.descriptionBarreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.description.sponsorshipHospital “Padre Alberto Buffoni” in Quininde´, Esmeraldas Province for their support
dc.language.isoeng
dc.publisherAmerican Thoracic Society
dc.rightsopen access
dc.subject.otherGeohelmintos
dc.subject.otherAtopia
dc.subject.otherChiado
dc.subject.otherAsma
dc.subject.otherInfância
dc.titleEffect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age
dc.typeArticle
dc.identifier.doi10.1164/rccm.201706-1222OC
dc.description.abstractenExposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. Objectives: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. Methods: A cohort of 2,404 neonates was followed to 5 years of age in a rural district in coastal Ecuador. Data on wheeze were collected by questionnaire and atopy was measured by allergen skin prick test reactivity to 10 allergens at 5 years. Stool samples from mothers and children were examined for geohelminths by microscopy. Measurements and Main Results: A total of 2,090 (86.9%) children were evaluated at 5 years. Geohelminths were observed in 45.5% of mothers and in 34.1% of children by 3 years. Wheeze and asthma were reported for 12.6% and 5.7% of children, respectively, whereas 14.0% had skin test reactivity at 5 years. Maternal geohelminths were associated with an increased risk of wheeze (adjusted odds ratio, 1.41; 95% confidence interval, 1.06–1.88), whereas childhood geohelminths over the first 3 years of life were associated with reduced risk of wheeze (adjusted odds ratio, 0.70; 95% confidence interval, 0.52–0.96) and asthma (adjusted odds ratio, 0.60; 95% confidence interval, 0.38–0.94) but not skin prick test reactivity. The effects on wheeze/asthma were greatest with later age of first infection, were observed only in skin test–negative children, but were not associated with parasite burden or specific geohelminths. Conclusions: Although maternal exposures to geohelminths may increase childhood wheeze, childhood geohelminths during the first 3 years may provide protection through a nonallergic mechanism. Registered as an observational study (ISRCTN41239086).
dc.creator.affilliationUniversidad Internacional del Ecuador. Facultad de Ciencias Medicas de la Salud y la Vida. Quito, Ecuador / Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador / Institute of Infection and Immunity. London, United Kingdom.
dc.creator.affilliationLaboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
dc.creator.affilliationLaboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
dc.creator.affilliationLaboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
dc.creator.affilliationLaboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, United Kingdom.
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
dc.creator.affilliationSt. George’s University of London. Population Health Research Institute. London, United Kingdom.
dc.subject.enGeohelminths
dc.subject.enAtopy
dc.subject.enWheeze
dc.subject.enAsthma
dc.subject.enChildhood
Appears in Collections:BA - IGM - Artigos de Periódicos

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