Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/28173

Tipo de documento
Artigo
Direito Autoral
Acesso restrito
Data de embargo
2050-01-01
Coleções
Compartilhar

Estatísticas
Metadata
Mostrar registro completo

HEMOCYTE DIFFERENTIATION MEDIATES INNATE IMMUNE MEMORY IN ANOPHELES GAMBIAE MOSQUITOES
Rodrigues, Janneth et al. | Data do documento: 2010
Autor(es)
Rodrigues, Janneth
Brayner, Fábio André
Alves, Luiz Carlos
Dixit, Rajnikant
Barillas-Mury, Carolina
Afiliação
tional Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil.
National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
Resumo em Inglês
Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.
Palavras-chave
Mosquito
Sistema Imune
Imunidade Inata
 
DeCS
Anopheles / imunologia
Anopheles / parasitologia
Bactérias / imunologia
Hemócitos / fisiologia
Imunidade Inata
Memória Imunológica
Plasmodium berghei / imunologia
Ratos
Diferenciação Celular
Contagem de Colônias, Microbiana
 
Referência
RODRIGUES, J. et al. Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes. Science, v. 329, n. 5997, p. 1353–1355, 10 set. 2010.
DOI
10.1126/science.1190689
ISSN
1095-9203