| Author | Rodrigues, Janneth | |
| Author | Brayner, Fábio André | |
| Author | Alves, Luiz Carlos | |
| Author | Dixit, Rajnikant | |
| Author | Barillas-Mury, Carolina | |
| Access date | 2018-08-16T12:51:01Z | |
| Available date | 2018-08-16T12:51:01Z | |
| Document date | 2010 | |
| Citation | RODRIGUES, J. et al. Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes. Science, v. 329, n. 5997, p. 1353–1355, 10 set. 2010. | pt_BR |
| ISSN | 1095-9203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28173 | |
| Sponsorship | Programa de Pesquisa Intramural da Divisão de Pesquisa Intramural, NIAID, National Institutes of Health. FB e LA foram financiados pelas agências do governo brasileiro e do CNPq, respectivamente. | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Mosquito | pt_BR |
| Subject in Portuguese | Sistema Imune | pt_BR |
| Subject in Portuguese | Imunidade Inata | pt_BR |
| Title | Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1126/science.1190689 | |
| Abstract | Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory. | pt_BR |
| Affilliation | tional Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil. | pt_BR |
| Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
| Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
| DeCS | Anopheles / imunologia | pt_BR |
| DeCS | Anopheles / parasitologia | pt_BR |
| DeCS | Bactérias / imunologia | pt_BR |
| DeCS | Hemócitos / fisiologia | pt_BR |
| DeCS | Imunidade Inata | pt_BR |
| DeCS | Memória Imunológica | pt_BR |
| DeCS | Plasmodium berghei / imunologia | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Diferenciação Celular | pt_BR |
| DeCS | Contagem de Colônias, Microbiana | pt_BR |
| Embargo date | 2050-01-01 | |
