Author | Costa, Af Ali Uthant Moreira Lima da | |
Author | Saldanha, Ana Cristina Rodrigues | |
Author | Leite, Bruno M. C. | |
Author | Ramos, Bruno | |
Author | Junior, Ibraim A. | |
Author | Noronha, Almério Libório Lopes de | |
Author | Bafica, Andre Luiz Barbosa | |
Author | Barral, Aldina Maria Prado | |
Author | Corbett, Carlos Eduardo Pereira | |
Author | Costa, Jackson Mauricio Lopes | |
Access date | 2011-08-30T18:15:23Z | |
Available date | 2011-08-30T18:15:23Z | |
Document date | 2004 | |
Citation | COSTA, Af Ali Uthant Moreira Lima da et al. Imaging exams of bone lesions in patients with diffuse cutaneous leishmaniasis (DCL). Acta Tropica, v.96, n. 1, p. 9-15, 2005. | pt_BR |
ISSN | 1873-6254 | |
URI | https://www.arca.fiocruz.br/handle/icict/2820 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Adolescente | pt_BR |
Subject in Portuguese | Adulto | pt_BR |
Subject in Portuguese | Osso e Ossos | pt_BR |
Subject in Portuguese | Feminino | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Leishmaniose Tegumentar Difusa | pt_BR |
Subject in Portuguese | Masculino | pt_BR |
Title | Imaging exams of bone lesions in patients with diffuse cutaneous leishmaniasis (DCL) | pt_BR |
Type | Article | pt_BR |
DOI | doi:10.1016/j.actatropica.2005.06.016 | |
Abstract | We studied bone lesion alterations in three patients with diffuse cutaneous leishmaniasis (DCL) by imaging exams (radiography
and scintigraphy) and histopathology. Two patients had bone lesions of distal extremities of hands and feet, and one
infiltrating plaques in the skin. The study was conducted at three specialized centers (Presidente Dutra Hospital/Nucleus of Tropical
Pathology, UFMA-MA; Gonc¸alo Moniz Research Center-FIOCRUZ-BA; Laboratory of Pathology of Infectious Diseases
(LIM-50), University of S˜ao Paulo, SP). Three-phase bone scintigraphy demonstrated high sensitivity and specificity for bone
lesions, showing increased uptake of the radiopharmaceutical at sites of active lesions. In contrast, radiography demonstrated
lytic lesions, cortical destruction and local osteopenia of the bone extremeties in two patients. Histopathological analysis showed
sequestration with presence of amastigote forms of Leishmania (osteomyelitis), mononuclear cells and macrophages containing
amastigote forms of Leishmania in one patient. These preliminary data indicate that imaging exams (radiography and scintigraphy)
are important in the evaluation of bone lesions in diffuse cutaneous leishmaniasis and should be included in the routine
histopathological diagnosis of the disease and follow-up of bone lesions | pt_BR |
Affilliation | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil. | pt_BR |
Affilliation | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil. | pt_BR |
Affilliation | Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil. | pt_BR |
Affilliation | Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil. | pt_BR |
Affilliation | Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
Affilliation | University of São Paulo. Laboratory of Immunopathology (LIM-50). São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
Subject | Diffuse cutaneous Leishmaniasis | pt_BR |
Subject | Bone alterations | pt_BR |
Subject | Scintigraphy | pt_BR |
Subject | Imaging exams | pt_BR |