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|Title:||Prevalence of High-Risk Human papillomavirus Genotypes and Predictors factors for Cervical Cancer in Unimmunized Brazilian Women without Cytological Abnormalities|
|Authors:||Simões, Rachel Siqueira de Queiroz|
Silva, Emmanuele Pariz
Barth, Ortrud Monika
|Affilliation:||Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.|
Universidade Itajaí. Vale do Itajaí, SC, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.
|Abstract:||HPV is the most common sexually transmitted disease based on its oncogenic activity as high-risk (hr) types, low-risk types (lr) and types of undetermined-risk depending upon the associated diseases. The aim of this study was to evaluate the HPV infection prevalence and to identify the risk factors as demographic, behavioral and biological variables related to cervical cancer in unimmunized and sexually active women patients attended at public health institutions. A cross-sectional study conducted from 2014 to 2016 was performed at Rio de Janeiro city. All women were randomly selected and submitted to clinical and sociodemographic investigation. About 100 cervical cell scrapings were collected with a cervical cytobrush during the gynecological examination. After nucleic acid amplification directed to a conserved region of the HPV L1 gene, high-risk type specific primers (HPV16/18/31/45) were performed for genotyping. Statistical analysis was applied to analyze the risk factors associated with HPV infection in 18 sociodemographics variables obtained from informative questionnaires. This study demonstrated by the Chi-square test that of the 100 participants, 20% (95% CI: 12-28) were DNA HPV positive. HPV 18 and 45 were the most frequently detected HPV types. Most women were currently not married (56%) and married or cohabitating (44%) (p<0.05). Psychosocial and psychosexual issues demonstrated that six percent of the women exhibit history of sexually transmitted diseases, except HIV, with 85% of women having sex with until to five partners (p<0.03) and 15% used oral contraceptives, while 71% did not use any type of condom (p<0.03). A previous history of STD was not significantly related. Cytological status was without alterations in the population investigated. This paper contributed to a better understanding about the natural history of HPV from of the pre-immunization prevalence study of the active sexually and clinical free lesions women in Brazil.|
|keywords:||Neoplasias do Colo do Útero|
|Citation:||SIMÕES, Rachel Siqueira de Queiroz; SILVA, Emmanuele Pariz; BARTH, Ortrud Monika. Prevalence of High-Risk Human papillomavirus Genotypes and Predictors factors for Cervical Cancer in Unimmunized Brazilian Women without Cytological Abnormalities. Advances in Biotechnology & Microbiology, v.8, n.5, 7p, Mar. 2018.|
|Appears in Collections:||IOC - Artigos de Periódicos|
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