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Title: Dengue during Pregnancy: A Study of Thirteen Cases
Authors: Alvarenga, Christiane Fernandes
Silami, Vânia Glória
Brasil, Patrícia
Boechat, Maria Elizabeth Herdy
Coelho, Janice
Nogueira, Rita Maria Ribeiro
Affilliation: Hospital Azevedo Lima. Serviços de Vigilância Sanitária. Niterói, RJ, Brasil.
Hospital Universitário Antonio Pedro. Departamento de Patologia. Niterói, RJ, Brasil.
Hospital Azevedo Lima. Serviços de Vigilância Sanitária. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.
Abstract: Problem statement: The principal aim was to evaluate the effects of dengue virus infection by dengue during pregnancy and analyze the histopathology of the placenta. Approach: A retrospective study was conducted with 13 pregnant women with dengue confirmed in the period from January-December 2002, during a widespread dengue type 3 epidemic in Rio de Janeiro. Maternal and newborn data were collected from patient files and medical records during hospitalization for research for identification of dengue IgM antibodies (PanBio, Australia). Virus isolation was performed on all fatal cases and anathomopathological studies and immunohistochemistry of the placenta were carried out in three cases. Results: Among the 13 women, 11 (84, 6%) were infected in the third quarter of pregnancy, 6 (54, 5%) of which resulting in premature birth and 4 cases (30, 7%) were classified as DHF, causing 2 deaths. Intense abdominal pain afflicted 6 patients (46, 2%) and 5 newborns presented low weight, however appropriate for the gestacional age. Conclusion: Dengue virus infection in pregnancy increases premature birth risk, especially if the infection occurs in the last quarter of pregnancy.
Keywords: Dengue
premature birth
keywords: Dengue
nascimento prematuro
Issue Date: 2009
Publisher: Science Publications
Citation: ALVARENGA, Christiane Fernandes; et al. Dengue during Pregnancy: A Study of Thirteen Cases, American Journal do Infectious Diseases, v.5, n.4, p.288-293, 2009.
ISSN: 1553-6203
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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