Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/30272
Type
ArticleCopyright
Restricted access
Embargo date
2025-08-30
Collections
- INI - Artigos de Periódicos [3381]
Metadata
Show full item record
ANALYSIS OF SERIOUS NON-AIDS EVENTS AMONG HIV-INFECTED ADULTS AT LATIN AMERICAN SITES
Cardiovascular disease
CD4 cell lymphocyte count
Cohort Studies
Liver diseases
Neoplasms
Author
Affilliation
Hospital Italiano y CICAL. Buenos Aires, Argentina.
Universidad de Buenos Aires. Instituto de Cálculo. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.
Hospital Parmenio Piñero. Buenos Aires, Argentina.
Hospital de Clínicas José de San Martín. Buenos Aires, Argentina.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Hospital JM Ramos Mejía y CICAL. Buenos Aires, Argentina.
Universidad de Buenos Aires. Instituto de Cálculo. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.
Hospital Parmenio Piñero. Buenos Aires, Argentina.
Hospital de Clínicas José de San Martín. Buenos Aires, Argentina.
Investigaciones Médicas en Salud (INMENSA). Lima, Peru.
Hospital JM Ramos Mejía y CICAL. Buenos Aires, Argentina.
Abstract
Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of followup) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P 5 0.0056, with an average difference of more than 100 cells/mL) and area under the CD4 cell curve in the year previous to index date (P 5 0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment.
Keywords
AIDSCardiovascular disease
CD4 cell lymphocyte count
Cohort Studies
Liver diseases
Neoplasms
Share