| Author | Grinsztejn, Beatriz | |
| Author | Veloso,Valdiléa G. | |
| Author | Friedman, Ruth K | |
| Author | Moreira, Ronaldo I | |
| Author | Luz, Paula Mendes | |
| Author | Campos, Dayse P | |
| Author | Pilotto, José H | |
| Author | Cardoso, Sandra W | |
| Author | Keruly, Jeanne C | |
| Author | Moore, Richard D | |
| Access date | 2018-11-28T18:27:00Z | |
| Available date | 2018-11-28T18:27:00Z | |
| Document date | 2009 | |
| Citation | GRINSZTEJN, Beatriz et al. Early mortality and cause of deaths in patients using HAART in Brazil and the United States. AIDS, v. 23, n. 16, p. 2107-2114, 2009. | pt_BR |
| ISSN | 1473-5571 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30291 | |
| Description | Acknowledgements: B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432. B.G., V.G.V. and R.D.M. conceived, designed, and coordinated the study, guided the discussion of the results, and drafted the manuscript. R.D.M. conducted the data analysis. D.P.C. and R.I.M. were responsible for data collection in Rio de Janeiro and participated in the discussion of the results. R.D.M. and J.C.K. were responsible for the data collection in Baltimore. R.K.F. and P.M.L. participated in the study design, discussion of the results, and in the writing of the manuscript. J.C.K., J.H.P. and S.W.C. participated in the study design and in the discussion of the results. | pt_BR |
| Sponsorship | B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and
the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National
Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432. | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Early mortality and cause of deaths in patients using HAART in Brazil and the United States | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1097/QAD.0b013e32832ec494 | |
| Abstract | Objective: To compare the early mortality pattern and causes of death among patients starting HAART in Brazil and the United States. Methods: We analyzed the combined data from two clinical cohorts followed at the Johns Hopkins AIDS Service in Baltimore, United States, and the Evandro Chagas Clinical Research Institute AIDS Clinic in Rio de Janeiro, Brazil. Participants included those who entered either cohort between 1999 and 2007 and were antiretroviral naive. Follow-up was at 1 year since HAART initiation. Cox proportional hazards regression analysis was used to assess the role of the city on the risk of death. Results: A total of 859 and 915 participants from Baltimore and Rio de Janeiro, respectively, were included. In Rio de Janeiro, 64.7% of deaths occurred within 90 days of HAART initiation; in Baltimore, 48.9% occurred between 180 and 365 days. AIDS-defining illness (61.8%) and non-AIDS-defining illness (55.6%) predominated as causes of death in Rio de Janeiro and Baltimore, respectively. Risk of death was similar in both cities (hazard ratio 1.04; P value = 0.95) after adjusting for CD4 T cell count, age, sex, HIV risk group, prior AIDS-defining illness, and Pneumocystis jirovecii pneumonia and Mycobacterium avium prophylaxis. Individuals with CD4 T cell count less than or equal to 50 cells/microl (hazard ratio 4.36; P = 0.001) or older (hazard ratio, 1.03; P = 0.03) were more likely to die. Conclusion: Although late HIV diagnosis is a problem both in developed and developing countries, differences in the timing and causes of deaths clearly indicate that, besides interventions for early HIV diagnosis, different strategies to curb early mortality need to be tailored in each country. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Johns Hopkins University. Department of Medicine. Baltimore, Maryland, United States. | pt_BR |
| Affilliation | Johns Hopkins University. Department of Medicine. Baltimore, Maryland, United States. | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | Causes of death | pt_BR |
| Subject | Cohort | pt_BR |
| Subject | Early mortality | pt_BR |
| Subject | HIV/AIDS | pt_BR |
