Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30398
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dc.contributor.authorOliveira, Camila Andrade
dc.contributor.authorRodrigues, Cibele Velloso
dc.contributor.authorAssis, Girley Francisco Machado de
dc.contributor.authorCarvalho, Beatriz Nogueira de
dc.contributor.authorGentz, Solange Henschke Lima
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorChaves, Daniel Gonçalves
dc.date.accessioned2018-12-05T15:29:48Z
dc.date.available2018-12-05T15:29:48Z
dc.date.issued2012
dc.identifier.citationOLIVEIRA, Camila Andrade et al. Cytokine profile and FVIII inhibitors development in haemophilia A. Haemophilia, v. 19, n. 3, :e139-42, 2013
dc.identifier.issn1351-8216
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/30398
dc.language.isoeng
dc.publisherBlackwell Science
dc.rightsrestricted access
dc.subject.otherperfil de citocina
dc.subject.otherInibidores de FVIII
dc.subject.otherhemofilia A
dc.titleCytokine profile and FVIII inhibitors development in haemophilia A
dc.typeArticle
dc.identifier.doi10.1111/hae.12096
dc.description.abstractenHaemophilia A is a hereditary bleeding disorder linked to the X chromosome characterized by a deficiency or defect in the coagulation factor VIII (FVIII). Individuals with this coagulopathy require constant infusions of FVIII to maintain their physical integrity and haemostasis. During treatment, some patients develop an immune response that produces antibodies to FVIII, also called inhibitors, affecting the pro-coagulant activity of this protein. Despite the clinical relevance of FVIII inhibitors, the immune mechanisms that lead to their production are not known. This study investigated the immunological cytokine profile using plasma from HA patients which were either positive or negative for FVIII inhibitors and from healthy individuals. The results showed that healthy individuals and HA patients that do not develop FVIII inhibitors have a mixed immune response profile with high secretion of IFN-c, TNF-a IL-2 and IL-5. In contrast, HA patients with FVIII inhibitors exhibited an anti-inflammatory/regulatory immune response characterized by low levels of all measured cytokines except for IL-4 and IL-10. This profile may be related to the development and maintenance of the FVIII inhibitors. By comparing the cytokine profiles of the three different groups we have established a model explaining the immune activation resulting in the production of FVIII inhibitors in haemophilia A patients.
dc.creator.affilliationFundacao Hemominas. Servico de Pesquisa. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundacao Hemominas. Servico de Pesquisa. Belo Horizonte, MG, Brasil/ Pontifıcia Universidade Catolica de Minas Gerais. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundacao Hemominas. Servico de Pesquisa. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundacao Hemominas. Laboratorio de Hematologia. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundacao Hemominas. Servico de Pesquisa. Belo Horizonte, MG, Brasil
dc.subject.encytokine profile
dc.subject.enFVIII inhibitors
dc.subject.enhaemophilia A
Appears in Collections:MG - IRR - Artigos de Periódicos

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