Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30399
Full metadata record
DC FieldValue
dc.contributor.authorMota, Ana Paula Lucas
dc.contributor.authorVilaça, Sandra Simone
dc.contributor.authorMercês Junior, Fernando Lucas das
dc.contributor.authorPinheiro, Melina de Barros
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorSilveira, Amanda Cardoso Oliveira
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorGomes, Karina Braga
dc.contributor.authorDusse, Luci Maria
dc.date.accessioned2018-12-05T15:51:14Z
dc.date.available2018-12-05T15:51:14Z
dc.date.issued2013
dc.identifier.citationMOTA, Ana Paula Lucas et al. Cytokines signatures in short and long-term stable renal transplanted patients. Cytokine, v. 62, n. 2, p.302-309, 2013
dc.identifier.issn1043-4666
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/30399
dc.language.isoeng
dc.publisherElsevier Science Ltd
dc.rightsrestricted access
dc.subject.othertransplante renal
dc.subject.othercitocinas
dc.subject.otherFunção de enxerto estável
dc.titleCytokines signatures in short and long-term stable renal transplanted patients.
dc.typeArticle
dc.identifier.doi10.1016/j.cyto.2013.03.001
dc.description.abstractenDespite the evidences showing the relevance of regulatory immune-mediated mechanisms to guarantee the stable graft function in renal transplanted patients, studies focusing on the immune response observed over a long-term period after renal transplantation are still limited. Several efforts have been done to establish novel biomarkers with relevant predictive values that could be used as prognostic laboratorial tools to monitor the complex network triggered through time after kidney transplantation. In this study, we have evaluated the pro-inflammatory and regulatory patterns of plasma cytokines in a group of 120 renal transplanted patients with stable graft function ranging from 1 to 160 months. Our data demonstrated an overall predominance of regulatory cytokines short-term after renal transplantation (1-24 months) with peaks of IL-4, IL-5 and IL-10. Moreover, a slight peak of TNF-α was observed 25-60 months after renal transplantation. Following a gap of stable cytokine profile (61-120 months), peaks of pro-inflammatory cytokines IL-8, IL-6, IL1β, TNF-α and IL-12 were observed later on (>120 months) after renal transplantation. Additionally, the categorical analysis of "low" or "high" cytokine producers re-enforce the occurrence of an overall regulatory status early-after stable renal graft function with a predominant pro-inflammatory pattern later on long-term renal transplantation. Taken together, our data suggest that IL-5 is a good biomarker associated with short-term stable renal function, whereas IL-12 seems to be a relevant pro-inflammatory element in long-term renal transplanted patients.
dc.creator.affilliationUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
dc.creator.affilliationHospital Felicio Rocho. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Nefrologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
dc.subject.enRenal transplantation
dc.subject.enCytokines
dc.subject.enStable graft function
Appears in Collections:MG - IRR - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Cytokines signatures in short.pdf4.37 MBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.