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dc.contributor.authorRocha, Marcele Neves
dc.contributor.authorNogueira, Paula Monalisa
dc.contributor.authorDemicheli, Cynthia
dc.contributor.authorOliveira, Ludmila Gonçalvez de
dc.contributor.authorSilva, Meiriane Mariano da
dc.contributor.authorFrézard, Frédéric
dc.contributor.authorMelo, Maria Norma
dc.contributor.authorSoares, Rodrigo Pedro Pinto
dc.date.accessioned2018-12-05T16:07:20Z
dc.date.available2018-12-05T16:07:20Z
dc.date.issued2013
dc.identifier.citationROCHA, Marcele Neves et al. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications, v. 2013, ID 961783, 7 pages, 2013
dc.identifier.issn1565-3633
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/30401
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subject.otherleishmaniose cutânea
dc.subject.otherLeishmania amazonensis
dc.titleCytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol.
dc.typeArticle
dc.identifier.doi10.1155/2013/961783
dc.description.abstractenLeishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. Lapachol [2-hydroxy-3-(3′-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens. In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides complexes with antimony (V), bismuth (V), and tin (IV) against L. amazonensis. All seven compounds exhibited antileishmanial activity, but most of the antimony (V) and bismuth (V) complexes were toxic against human HepG2 cells and murine macrophages. The best IC50 values (0.17 0.03 and 0.10 0.11 g/mL) were observed for Tin (IV) complexes (3) [(Lp)(Ph3Sn)] and (6) (Ph3SnCl2), respectively. Their selective indexes (SIs) were 70.65 and 120.35 for HepG2 cells, respectively. However, while analyzing murine macrophages, the SI decreased. Those compounds were moderately toxic for HepG2 cells and toxic for murine macrophages, still underlying the need of chemical modification in this class of compounds.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
dc.subject.enCutaneous leishmaniasis
dc.subject.enLeishmania amazonensis
Appears in Collections:MG - IRR - Artigos de Periódicos

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