| Author | Leite, Maria Lea Correa | |
| Author | Moriguchi, Emílio Hideyuki | |
| Author | Costa, Maria Fernanda Furtado Lima | |
| Access date | 2018-12-07T18:03:47Z | |
| Available date | 2018-12-07T18:03:47Z | |
| Document date | 2013 | |
| Citation | LEITE, Maria Lea Correa; MORIGUCHI, Emilio Hideyuki; COSTA, Maria Fernanda Furtado Lima. Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008). Maturitas, v. 76, n. 1, p. 57-63, 2013. | pt_BR |
| ISSN | 0378-5122 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30427 | |
| Language | eng | pt_BR |
| Publisher | Elsevier/North Holland Biomedical Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Consumo de álcool | pt_BR |
| Subject in Portuguese | Apolipoproteína E | pt_BR |
| Subject in Portuguese | Pressão sanguínea | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Menopausa | pt_BR |
| Title | Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008) | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.maturitas.2013.05.012 | |
| Abstract | Objectives: To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design: A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis. Results: Alcohol consumption was associated with high levels of systolic and diastolic BP in an age × genotype-dependent manner only in the non-obese women (BMI < 27 kg/m2). Among those with the ɛ3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg (p = 0.022) and 10.7 mmHg (p = 0.002), and disappeared in the older age groups, in which drinking was associated with systolic/diastolic hypertension if the non-obese women were ɛ4 carriers.
Conclusion: In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the ɛ3/3 ApoE genotype, and late in ɛ4 carriers. We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices. | pt_BR |
| Affilliation | Institute of Biomedical Technologies. National Research Council.Milan, Italy. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Alcohol consumption | pt_BR |
| Subject | Apolipoprotein E | pt_BR |
| Subject | Blood pressure | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Menopause | pt_BR |
| Embargo date | 2020-01-01 | |
