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AutorKochunov, Peter
AutorWey, Hsiao-Ying
AutorFox, Peter
AutorLancaster, Jack
AutorDavis, Michael
AutorWang, Danny
AutorLin, Ai-Ling
AutorBastarrachea, Raul
AutorAndrade, Marcia
AutorMattern, Vicki
AutorFrost, Patrice
AutorHiggins, Paul
AutorComuzzie, Anthony
AutorVoruganti, Venkata
Data de acesso2018-12-14T18:23:28Z
Data de disponibilização2018-12-14T18:23:28Z
Data do publicação2017
CitaçãoKOCHUNOV, Peter et al. Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.). Frontiers in Neuroscience. v. 11, p. 1-12, fev. 2017.pt_BR
ISSN1662-4548pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/30600
Idiomaengpt_BR
EditorFrontiers Mediapt_BR
Direito Autoralopen accesspt_BR
Palavras-chaveDesafio Hiperglicêmicopt_BR
Palavras-chaveFluxo Sanguíneo Cerebralpt_BR
Palavras-chaveImagem de Perfusãopt_BR
Palavras-chaveRede de Estado de Repousopt_BR
Palavras-chaveRede de Estado Padrãopt_BR
Palavras-chaveRotulagem da Rotação Arterialpt_BR
TítuloChanges in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.)pt_BR
Tipo do documentoArticlept_BR
DOI10.3389/fnins.2017.00049
Resumo em InglêsChanges in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38.9 mg/dL and declined to 133.4 ± 22.0 mg/dL, at the end of the experiment. Regional CBF changes consisted of four clusters: cerebral cortex, thalamus, hypothalamus, and mesencephalon. Increases in the hypothalamic blood flow occurred concurrently with the regulatory response to systemic glucose change, whereas CBF declined for other clusters. The return to baseline of hypothalamic blood flow was observed while CBF was still increasing in other brain regions. The spatial pattern of extra-hypothalamic CBF changes was correlated with the patterns of several cerebral networks including the default mode network. These findings suggest that hypothalamic blood flow response to systemic glucose levels can potentially be explained by regulatory activity. The response of extra-hypothalamic clusters followed a different time course and its spatial pattern resembled that of the default-mode network.pt_BR
AfiliaçãoMaryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MA, USA / Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Southwest National Primate Research Center, San Antonio, TX, USA.pt_BR
AfiliaçãoResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.pt_BR
AfiliaçãoResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.pt_BR
AfiliaçãoResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.pt_BR
AfiliaçãoResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.pt_BR
AfiliaçãoAhmanson-Lovelace Brain Mapping Center, University of California at Los Angeles, Los Angeles, CA, USA / Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.pt_BR
AfiliaçãoResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.pt_BR
AfiliaçãoSouthwest National Primate Research Center, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.pt_BR
AfiliaçãoDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.pt_BR
AfiliaçãoSouthwest National Primate Research Center, San Antonio, TX, USA.pt_BR
AfiliaçãoDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.pt_BR
AfiliaçãoDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.pt_BR
AfiliaçãoDepartment of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.pt_BR
Palavras-chave em inglêsHyperglycemic Challengept_BR
Palavras-chave em inglêsCerebral Blood Flowpt_BR
Palavras-chave em inglêsPerfusion Imagingpt_BR
Palavras-chave em inglêsResting State Networkpt_BR
Palavras-chave em inglêsDefault State Networkpt_BR
Palavras-chave em inglêsArterial Spin Labelingpt_BR
e-ISSN1662-453X


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