Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30652
Title: Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi
Authors: Batista, Denise da Gama Jaén
Silva, Patrícia Bernardino da
Lachter, Daniela R.
Silva, Renata S.
Aucelio, Ricardo Q.
Louro, Sonia R. W.
Beraldo, Heloisa
Soeiro, Maria de Nazaré C.
Teixeira, Letícia R.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Abstract: Thiosemicarbazones are known to be active against different pathogenic microorganisms including Trypanosoma cruzi, the etiological agent of Chagas disease. In the search for new therapeutic drugs against this illness, the complexes [Mn(H4NO2Fo4M)2Cl2] (1), [Mn(H4NO2Ac4M)2Cl2] (2) and [Mn(H4NO2 Bz4M)2Cl2] (3) of N4-methyl-4-nitrobenzaldehyde thiosemicarbazone (H4NO2Fo4M), N4-methyl-4-nitroacetophenone thiosemicarbazone (H4NO2Ac4M) and N4-methyl-4-nitrobenzophenone thiosemicarbazone (H4NO2Bz4M) were obtained and screened in vitro against bloodstream and intracellular forms of T. cruzi. H4NO2Fo4M, H4NO2Ac4M and their Mn(II) complexes displayed poor effect on bloodstream trypomastigotes, with IC50 values ranging from 68 to >200 lM. However, although H4NO2Bz4M was also not active, its corresponding Mn(II) complex presented high effect on this T. cruzi form, with an IC50 value of 19 lM. The effect of complex (3), against trypomastigotes of T. cruzi supports further in vitro as well as in vivo studies.
Keywords: Trypanosoma cruzi
Chagas Disease
Chemotherapy
Nitro-thiosemicarbazones
Mn(II) complexes
keywords: Trypanosoma cruzi
Doença de Chagas
Quimioterapia
Issue Date: 2010
Publisher: Elsevier
Citation: BATISTA, Denise da Gama Jaén; et al. Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi. Polyhedron, v.29, p.2232–2238, Apr. 2010.
DOI: 10.1016/j.poly.2010.04.023
ISSN: 0277-5387
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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