Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30717
Full metadata record
DC FieldValue
dc.contributor.authorCubillos-Angulo, Juan Manuel
dc.contributor.authorArriaga, María Belen
dc.contributor.authorSilva, Elisângela C.
dc.contributor.authorMüller, Beatriz de Lima Alessio
dc.contributor.authorRamalho, Daniela Maria de Paula
dc.contributor.authorFukutani, Kiyoshi Ferreira
dc.contributor.authorMiranda, Pryscila Fernandes Campino
dc.contributor.authorMoreira, Adriana S. R.
dc.contributor.authorRuffino Netto, Antonio
dc.contributor.authorSilva, Jose Roberto Lapa e
dc.contributor.authorSterling, Timothy R.
dc.contributor.authorKritski, Afrânio Lineu
dc.contributor.authorOliveira, Martha M.
dc.contributor.authorAndrade, Bruno de Bezerril
dc.date.accessioned2018-12-20T13:12:03Z
dc.date.available2018-12-20T13:12:03Z
dc.date.issued2018
dc.identifier10.1093/cid/ciy1001
dc.identifier.citationCUBILLOS-ANGULO, J. M. et al. Polymorphisms in TLR4 and TNFA and risk of mycobacterium tuberculosis infection and development of active disease in contacts of tuberculosis cases in Brazil: A prospective cohort study. Clinical Infectious Disease, p. 1-35, Nov. 2018.
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/30717
dc.description.sponsorshipThis work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Instituto Nacional de Ciência e Tecnologia (INCT, grant number: 573548/2008-0) and Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ, grant number: E-26/110.974/2011). AK is the recipient of a career award from CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). The work from BBA and KFF was supported by intramural research program from FIOCRUZ and from the National Institutes of Health (U01AI115940). JMC-A was supported by the Organization of American States - Partnerships Program for Education and Training (OAS-PAEC). MBA receives a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB).
dc.language.isoeng
dc.publisherOxfor University Press
dc.rightsopen access
dc.titlePolymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
dc.typePreprint
dc.description.abstractenBackground: The role of genetic polymorphisms in latent tuberculosis (TB) infection and progression to active TB is not fully understood. Methods: We tested the single nucleotide polymorphisms (SNPs) rs5743708 (TLR2), rs4986791 (TLR4), rs361525 (TNFA), rs2430561 (IFNG) rs1143627 (IL1B) as risk factors for tuberculin skin test (TST) conversion or development of active TB in contacts of active TB cases. Contacts of microbiologically confirmed pulmonary TB cases were initially screened for longitudinal evaluation up to 24 months, with clinical examination and serial TST, between 1998 and 2004 at a referral center in Brazil. Data and biospecimens were collected from 526 individuals who were contacts of 177 active TB index cases. TST conversion was defined as ≥5 f TST result (0 mm) at baseline or month 4 visit. Independent associations were tested using logistic regression models.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / State University of North Fluminense Darcy Ribeiro. Recognize the Biology Laboratory. Center of Bioscience and Biotechnology. Rio de Janeiro, RJ, Brazil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Osvaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
dc.creator.affilliationVanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Universidade Salvador. Laureate University. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
dc.subject.enSingle nucleotide polymorphism
dc.subject.enTuberculin skin test
dc.subject.enMycobacterium tuberculosis
dc.subject.enTumor necrosis factor
dc.subject.enToll-like receptor
dc.peerreviewedNão
dc.publicationstatusNão Publicado
Appears in Collections:CDTS - Artigos de Periódicos
IOC - Preprint
BA - IGM - Preprint

Files in This Item:
File Description SizeFormat 
Cubillos Angulo. J. Polymorphisms in TLR4 and TNFA...2018.pdf786.44 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.