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dc.contributor.authorBermúdez-Aza, Elkin Hernan
dc.contributor.authorKerr, Ligia Regina Franco Sansigolo
dc.contributor.authorKendall, Carl
dc.contributor.authorPinho, Adriana Araujo
dc.contributor.authorMello, Maeve Brito de
dc.contributor.authorMota, Rosa Salani
dc.contributor.authorGuimarães, Mark Drew Crosland
dc.contributor.authorAlencar, Cecilia Salete
dc.contributor.authorBrito, Ana Maria de
dc.contributor.authorDourado, Ines Costa
dc.contributor.authorBatista, Sonia Maria da
dc.contributor.authorAbreu, Fabiano
dc.contributor.authorOliveira, Lisangela Cristina de
dc.contributor.authorMoraes, Adão Souza de
dc.contributor.authorBenzaken, Adele Schwartz
dc.contributor.authorMerchan-Hamann, Edgar
dc.contributor.authorFreitas, Gisele Maria Brandão de
dc.contributor.authorMcFarland, Willi
dc.contributor.authorAlbuquerque, Elizabeth
dc.contributor.authorRutherford, George W.
dc.contributor.authorSabino, Ester
dc.identifier.citationBERMÚDEZ-AZA, E. H. et al. Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex with Men in Brazil. Journal of Acquired Immune Deficiency Syndromes (1999), v. 57 Suppl 3, p. S186-192, ago. 2011.
dc.description*Universidade Federal de São Paulo, São Paulo, Brazil; †Universidade Federal do Ceará; ‡Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; §Escola Nacional de Saúde Pública/Fiocruz; kCICT/Fiocruz; {Universidade Federal de Minas Gerais; **Centro de Pesquisas Aggeu Magalhães/Fiocruz; ††Instituto de Saúde Coletiva/Universidade Federal da Bahia; ‡‡Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; §§Secretaria Municipal de Saúde de Santos; kkUniBrasil; {{Secretaria Municipal de Saúde de Itajaí; ***Fundação Alfredo da Matta; †††Universidade de Brasília; ‡‡‡Secretaria Municipal de Saúde de Campo Grande; §§§University of California, San Francisco; and kkkLIM 03, Universidade de São Paulo, São Paulo, Brazil.
dc.description.sponsorshipDepartamento de DST, AIDS Hepatites Virais do Ministério da Saúde (CSV 234/07) e FAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulo Paulo (2004 / 15856-9) e CAPES.
dc.rightsrestricted access
dc.titleAntiretroviral drug resistance in a respondent-driven sample of HIV-infected men who have sex with men in Brazil
dc.description.abstractenBackground: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in communityrecruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil. Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIVpositive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapyexperienced (AE) and 99 (69.2%) antiretroviral therapy-naı¨ve (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines. Results: The most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). The overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). The prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). The most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases). Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.
dc.subject.enMen who have sex with men
dc.subject.enRespondent-driven sampling
dc.subject.enAntiretroviral resistance
dc.subject.decsSubstituição de aminoácidos
dc.subject.decsAnti-retrovirais / farmacologia
dc.subject.decsAnti-retrovirais / uso terapêutico
dc.subject.decsAnálise de Cluster
dc.subject.decsColeção de dados
dc.subject.decsResistência a Medicamentos Virais
dc.subject.decsInfecções por HIV / fármaco terapia
dc.subject.decsInfecções por HIV / virologia
dc.subject.decsProtease do HIV / genética
dc.subject.decsTranscriptase reversa do HIV / genética
dc.subject.decsHIV-1 / classificação
dc.subject.decsHIV-1 / efeitos de drogas
dc.subject.decsHIV-1 / genética
dc.subject.decsHIV-1 / isolamento e purificação
dc.subject.decsHomossexualidade masculina
dc.subject.decsDados de Sequencia Molecular
dc.subject.decsMutação, Missense
dc.subject.decsAnálise de Sequência, DNA
dc.subject.decsPopulação urbana
Appears in Collections:PE - IAM - Artigos de Periódicos

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