Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30920
Full metadata record
DC FieldValue
dc.contributor.authorSoeiro, Maria Nazaré C.
dc.contributor.authorDantas, Andréia P.
dc.contributor.authorDaliry, Anissa
dc.contributor.authorSilva, Cristiane F. da
dc.contributor.authorBatista, Denise G. J.
dc.contributor.authorSouza, Elen M. de
dc.contributor.authorOliveira, Gabriel M.
dc.contributor.authorSalomão, Kelly
dc.contributor.authorBatista, Marcos Meuser
dc.contributor.authorPacheco, Michelle G. O.
dc.contributor.authorSilva, Patrícia Bernardino da
dc.contributor.authorSanta Rita, Ricardo M.
dc.contributor.authorMenna Barreto, Rubem F. S.
dc.contributor.authorBoykin, David W.
dc.contributor.authorCastro, Solange Lisboa de
dc.date.accessioned2019-01-08T14:21:23Z
dc.date.available2019-01-08T14:21:23Z
dc.date.issued2009
dc.identifier.citationSOEIRO, Maria Nazaré C. et al. Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies. Mem Inst Oswaldo Cruz, v.104, Suppl. I, p.301-310, 2009.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/30920
dc.language.isoeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subject.otherTrypanosoma cruzi
dc.subject.otherDoença de Chagas
dc.subject.otherquimioterapia experimental
dc.subject.otherdiamidinas aromáticas
dc.subject.otherprópolis
dc.subject.othernaftoquinonas
dc.titleExperimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
dc.typeArticle
dc.description.abstractenChagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationUniversidade Federal de Goiás. Campus Jataí. Jataí, GO, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationGeorgia State University. Department of Chemistry. Atlanta, Georgia, USA.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas Disease
dc.subject.enexperimental chemotherapy
dc.subject.enaromatic diamidines
dc.subject.enpropolis
dc.subject.enN,N-dimethyl-propenamines
dc.subject.ennaphthoquinones
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
anissa_dallari_etal_IOC_2009.pdf805.75 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.