Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31001
Title: Extracellular Vesicle-Associated Transitory Cell Wall Components and Their Impact on the Interaction of Fungi with Host Cells
Authors: Nimrichter, Leonardo
Souza, Marcio M. de
Del Poeta, Maurizio
Nosanchuk, Joshua D.
Joffe, Luna
Tavares, Patricia de M.
Rodrigues, Marcio L.
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Glicobiologia de Eucariotos. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Glicobiologia de Eucariotos. Rio de Janeiro, RJ, Brazil.
Stony Brook University. Department of Molecular Genetics and Microbiology. Stony Brook, NY, USA / Veterans Administration Medical Center. Northport, NY, USA.
Albert Einstein College of Medicine. Department of Microbiology and Immunology and Medicine. Bronx, NY, USA.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Glicobiologia de Eucariotos. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Glicobiologia de Eucariotos. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Glicobiologia de Eucariotos. Rio de Janeiro, RJ, Brazil.
Abstract: Classic cell wall components of fungi comprise the polysaccharides glucans and chitin, in association with glycoproteins and pigments. During the last decade, however, system biology approaches clearly demonstrated that the composition of fungal cell walls include atypical molecules historically associated with intracellular or membrane locations. Elucidation of mechanisms by which many fungal molecules are exported to the extracellular space suggested that these atypical components are transitorily located to the cell wall. The presence of extracellular vesicles (EVs) at the fungal cell wall and in culture supernatants of distinct pathogenic species suggested a highly functional mechanism of molecular export in these organisms. Thus, the passage of EVs through fungal cell walls suggests remarkable molecular diversity and, consequently, a potentially variable influence on the host antifungal response. On the basis of information derived from the proteomic characterization of fungal EVs from the yeasts Cryptoccocus neoformans and Candida albicans and the dimorphic fungi Histoplasma capsulatum and Paracoccidioides brasiliensis, our manuscript is focused on the clear view that the fungal cell wall is much more complex than previously thought.
Keywords: Fungal cell wall
Extracellular vesicles
Proteomics
Host cell
Cell wall remodeling
Issue Date: 2016
Publisher: Frontiers in Microbiology
Citation: NIMRICHTER, L. et al. Extracellular vesicle-associated transitory cell wall components and their impact on the interaction of fungi with host cells. Frontiers in Microbiology, v. 7, p. 1-11, 2016.
DOI: 10.3389/fmicb.2016.01034
ISSN: 1664-302X
Copyright: open access
Appears in Collections:CDTS - Artigos de Periódicos

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