Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31031
Title: In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi
Authors: Daliry, Anissa
Silva, Patrícia B. da
Silva, Cristiane F. da
Batista, Marcos Meuser
Castro, Solange L. de
Tidwell, Richard R.
Soeiro, Maria de Nazaré C.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
University of North Carolina at Chapel Hill. Department of Pathology and Laboratory Medicine. Chapel Hill, NC, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Abstract: Aromatic diamidines (ADs) have been recognized as promising antiparasitic agents. Therefore, in the present work, the in vitro trypanocidal effect of 11 ADs upon the relevant clinical forms of Trypanosoma cruzi was evaluated, as well as determining their toxicity to mammalian cells and their subcellular localization.
Keywords: Chemotherapy
Chagas Disease
kDNA
Intracellular localization
keywords: Doença de Chagas
Quimioterapia
Localização intracelular
DNA de Cinetoplasto
DeCS: DNA de Cinetoplasto
Issue Date: 2009
Publisher: Oxford University Press
Citation: DALIRY, Anissa et al. In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi. Journal of Antimicrobial Chemotherapy, v. 64, p. 747–750, 2009.
DOI: 10.1093/jac/dkp290
ISSN: 0305-7453
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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