Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31111
Title: Acute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice
Authors: Oliveira, Gabriel Melo de
Silva, Tshaca Mahatma da
Batista, Wanderson Silva
Franco, Marcello
Schor, Nestor
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Estadual Paulista. Escola Paulista de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.
Universidade Estadual Paulista. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Nefrologia. São Paulo, SP, Brasil.
Abstract: Experimental acute infection with Trypanosoma cruzi in mice promotes an intense myocarditis and other systemic changes. However, the network of pathophysiological disorders and renal injury caused by the infection has not been elucidated. Our previous results with a murine model observed a discrete acute myocarditis and high mortality with significant inflammatory kidney injury with T. cruzi infection. The aim of this study was to investigate the mechanisms of kidney injury caused by the parasite in mice during the experimental acute phase. Results employing BALB/c mice infected with T. cruzi of Y strain showed renal injury on the 6th day postinfection (dpi) caused by a transitory decrease of renal blood flow. Acute kidney injury (AKI) was also observed similar to the model of ischemia/reperfusion lesion in these infected mice. The injury was not related to the presence (or multiplication) of parasites. Only rare nests were microscopically detected, and the presence of scattered parasites in renal parenchyma was seen on the 15th dpi. Thus, it was observed that during the acute phase of the disease, AKI in infected mice is linked to early cardiovascular effects, including heart failure, caused by striking inflammatory lesions in the myocardium, which lead to the high mortality rate of animals.
Keywords: Trypanosoma cruzi
Renal ischemic/reperfusion lesion
Acute experimental infection
Mice
keywords: Trypanosoma cruzi
Infecção experimental aguda
Lesão isquêmica
Reperfusão renal
Camundongos
Issue Date: 2009
Publisher: Springer Verlag (Germany)
Citation: OLIVEIRA, Gabriel Melo de; et al. Acute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice. Parasitol Res., v.106, p.111–120, 2009.
DOI: 10.1007/s00436-009-1637-0
ISSN: 0932-0113
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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