Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31267
Title: Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
Authors: Camara, Edmundo José Nassri
Mendonca, Vitor Rosa Ramos
Souza, Ligia C. L.
Carvalho, Juliana S.
Lessa, Rudá Alves
Gatto, Ramon
Barreto, Luan Oliveira
Chiacchio, Giulianna
Amarante, Eduardo
Cunha, Monaliza
Silva, Luis S. Alves
Guimarães, Benelson A. C.
Barral Netto, Manoel
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.
Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
Climecar. Clinica de Cardiologia. Itaberaba, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia. São Paulo, SP, Brasil.
Abstract: The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear. Methodology and findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirtythree patients had been previously treated with benznidazole and 33 had never been treated. The treated group exhibited higher levels of IL-17 (median 142.45 1.22 pg/ml, P = 0.025), which was the only one significantly associated with Bz treatment, especially after adjusting for time of disease and NYHA class (P = 0.024; OR 1.006, 95% CI 1.001-1.010). Compared to untreated patients, the treated group exhibited higher median values of mitral annular E’ lateral (13.0 10.0 cm/s, P = 0.038), S’ infero-lateral (8.9 7.6 cm/s, P = 0.013), S’ septal (8.5 7.4 cm/s, P = 0.034), mean S’ (9.0 7.9 cm/s, P = 0.013) and tricuspid annular S’ (13.3 11.1 cm/s, P = 0.001) and lower values of E/E’ septal (7.2 9.5 cm/s, P = 0.049). After adjustment for time of disease and NYHA class, S’ infero-lateral (P = 0.031), mean S’ (P = 0.049) and S’ tricuspid (P = 0.024) persisted as significantly associated with treatment. Conclusion: The present findings suggest that the group of CCD patients treated with Bz displayed increased plasma levels of IL-17 and preserved myocardial function, reinforcing the idea that Bz treatment may be beneficial.
Keywords: Chagas’ disease
Benznidazol treatment
Immune response
Cytokines
Echocardiographic
Tissue Doppler
keywords: Doença de Chagas
Tratamento com benznidazol
Resposta imune
Citocinas
Ecocardiográfico
Doppler tecidual
Issue Date: 2019
Publisher: Elsevier
Citation: CAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019.
DOI: 10.1016/j.ijid.2018.11.369
ISSN: 1201-9712
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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