Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31362
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dc.contributor.authorSouza, Thiara Manuele Alves de Souza
dc.contributor.authorNogueira, Fernanda de Bruycker
dc.contributor.authorCarneiro, Thaís Chouin
dc.contributor.authorFaria, Nieli Rodrigues da Costa
dc.contributor.authorNunes, Priscila Conrado Guerra
dc.contributor.authorHeringer, Manoela
dc.contributor.authorLima, Monique da Rocha Queiroz
dc.contributor.authorCorrêa, Jéssica Badolato
dc.contributor.authorCipitelli, Márcio da Costa
dc.contributor.authorAzereedo, Elzinandes Leal de
dc.contributor.authorNogueira, Rita Maria Ribeiro
dc.contributor.authorSantos, Flávia Barreto dos
dc.contributor.authorRibeiro, Edcelha D`Athaide
dc.contributor.authorCorrêa, Valmir Corrêa e
dc.contributor.authorDamasco, Paulo Vieira
dc.contributor.authorSantos, Carla Cunha
dc.date.accessioned2019-01-31T15:32:23Z
dc.date.available2019-01-31T15:32:23Z
dc.date.issued2018
dc.identifier.citationSOUZA, Thiara Manuele Alves de; et al. Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016. Viruses, v.10, n.623, 17p, 2018.
dc.identifier.issn1999-4915
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/31362
dc.language.isoeng
dc.publisherMDPI
dc.rightsopen access
dc.subject.otherChikungunya vírus
dc.subject.otherCoinfecção
dc.subject.otherVigilância
dc.subject.otherGenótipo asiático
dc.subject.otherBrasil
dc.titleFollowing in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016
dc.typeArticle
dc.identifier.doi10.3390/v10110623
dc.description.abstractenCurrently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in 2014 when the first autochthonous cases were reported and in Rio de Janeiro (RJ) in 2016. We further performed molecular characterization and genotyping of representative strains. In AP, 51.4% of the suspected cases were confirmed for CHIKV, 71.0% (76/107). Of those, 24 co-infections by CHIKV/DENV, two by CHIKV/DENV-1, and two by CHIKV/DENV-4 were observed. In RJ, 76.9% of the suspected cases were confirmed for CHIKV and co-infections by CHIKV/DENV (n = 8) and by CHIKV/ZIKV (n = 17) were observed. Overall, fever, arthralgia, myalgia, prostration, edema, exanthema, conjunctival hyperemia, lower back pain, dizziness, nausea, retroorbital pain, and anorexia were the predominating chikungunya clinical symptoms described. All strains analyzed from AP belonged to the Asian genotype and no amino acid changes were observed. In RJ, the East-Central-South-African genotype (ECSA) circulation was demonstrated and no E1-A226V mutation was observed. Despite this, an E1-V156A substitution was characterized in two samples and for the first time, the E1-K211T mutation was reported in all samples analyzed.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationLaboratório Central do Amapá. Macapá, AP, Brasil.
dc.creator.affilliationLaboratório de Fronteira. Oiapoque, AP, Brasil.
dc.creator.affilliationRio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. RJ, Brasil.
dc.creator.affilliationRio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil
dc.subject.enChikungunya virus
dc.subject.enSurveillance
dc.subject.enco-infection
dc.subject.enECSA genotype
dc.subject.enAsian genotype
dc.subject.enBrazil
dc.identifier.eissn1999-4915
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