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FATAL SEPTIC SHOCK CAUSED BY PARACOCCIDIOIDES BRASILIENSIS PHYLOGENETIC SPECIES S1 IN A YOUNG IMMUNOCOMPETENT PATIENT: A CASE REPORT
Choque séptico
Interação parasita-hospedeiro
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Abstract
The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused
by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such
as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and
diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the
potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to
be involved in severe cases of PCM.
Keywords in Portuguese
Paracoccidioides brasiliensis S1Choque séptico
Interação parasita-hospedeiro
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