Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31439
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dc.contributor.authorAzevedo, Suwellen S. D. de
dc.contributor.authorDelatorre, Edson
dc.contributor.authorCôrtes, Fernanda H.
dc.contributor.authorHoagland, Brenda
dc.contributor.authorGrinsztejn, Beatriz
dc.contributor.authorVeloso, Valdilea G.
dc.contributor.authorSouza, Thiago Moreno L.
dc.contributor.authorMorgado, Mariza G.
dc.contributor.authorBello, Gonzalo
dc.date.accessioned2019-02-05T17:37:57Z
dc.date.available2019-02-05T17:37:57Z
dc.date.issued2019
dc.identifier.citationAZEVEDO, Suwellen S. D. de et al. HIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection. AIDS, v. 33, n. 3, p. 399-410, 2019.
dc.identifier.issn0269-9370
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/31439
dc.language.isoeng
dc.publisherWolters Kluwer
dc.rightsrestricted access
dc.titleHIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection
dc.typeArticle
dc.identifier.doi10.1097/QAD.0000000000002090
dc.description.abstractenObjective: The aim of this study was to investigate the impact of intersubtype HIV-1 superinfection on viremia, reservoir reseeding, viral evolution and disease progression in HIV controllers (HIC). Design: A longitudinal analysis of two Brazilian HIC individuals (EEC09 and VC32) previously identified as dually infected with subtypes B and F1 viruses. Methods: Changes in plasma viremia, total HIV-1 DNA levels, CD4þ T-cell counts and HIV-1 quasispecies composition were measured over time. HIV-1 env diversity in peripheral blood mononuclear cell (PBMC) and plasma samples was accessed by single genome amplification and next-generation sequencing approaches, respectively. Viral evolution was evaluated by estimating nucleotide diversity and divergence. Results: Individual EEC09 was probably initially infected with a CCR5-tropic subtype B strain and sequentially superinfected with a CXCR4-tropic subtype B strain and with a subtype F1 variant. Individual VC32 was infected with a subtype B strain and superinfected with a subtype F1 variant. The intersubtype superinfection events lead to a moderate increase in viremia and extensive turnover of viral population in plasma but exhibited divergent impact on the size and composition of cell-associated HIV DNA population. Both individuals maintained virologic control (<2000 copies/ ml) and presented no evidence of viral evolution or immunologic progression for at least 2 years after the intersubtype superinfection event. Conclusion: These data revealed that some HIC are able to repeatedly limit replication and evolution of superinfecting viral strains of a different subtype with no signs of disease progression.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.subject.enDisease progression
dc.subject.enHIV controllers
dc.subject.enReservoir
dc.subject.enSuperinfection
dc.subject.enViral load
Appears in Collections:CDTS - Artigos de Periódicos
IOC - Artigos de Periódicos
INI - Artigos de Periódicos

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