| Author | Azevedo, Suwellen S. D. de | |
| Author | Delatorre, Edson | |
| Author | Côrtes, Fernanda H. | |
| Author | Hoagland, Brenda Regina de Siqueira | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso,Valdiléa G. | |
| Author | Souza, Thiago Moreno L. | |
| Author | Morgado, Mariza G. | |
| Author | Bello, Gonzalo | |
| Access date | 2019-02-05T17:37:57Z | |
| Available date | 2019-02-05T17:37:57Z | |
| Document date | 2019 | |
| Citation | AZEVEDO, Suwellen S. D. de et al. HIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection. AIDS, v. 33, n. 3, p. 399-410, 2019. | pt_BR |
| ISSN | 0269-9370 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31439 | |
| Language | eng | pt_BR |
| Publisher | Wolters Kluwer | pt_BR |
| Rights | restricted access | |
| Title | HIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1097/QAD.0000000000002090 | |
| Abstract | Objective: The aim of this study was to investigate the impact of intersubtype HIV-1 superinfection on viremia, reservoir reseeding, viral evolution and disease progression in HIV controllers (HIC). Design: A longitudinal analysis of two Brazilian HIC individuals (EEC09 and VC32)
previously identified as dually infected with subtypes B and F1 viruses.
Methods: Changes in plasma viremia, total HIV-1 DNA levels, CD4þ T-cell counts and HIV-1 quasispecies composition were measured over time. HIV-1 env diversity in peripheral blood mononuclear cell (PBMC) and plasma samples was accessed by single genome amplification and next-generation sequencing approaches, respectively. Viral evolution was evaluated by estimating nucleotide diversity and divergence. Results: Individual EEC09 was probably initially infected with a CCR5-tropic subtype B strain and sequentially superinfected with a CXCR4-tropic subtype B strain and
with a subtype F1 variant. Individual VC32 was infected with a subtype B strain and superinfected with a subtype F1 variant. The intersubtype superinfection events lead to a moderate increase in viremia and extensive turnover of viral population in plasma but exhibited divergent impact on the size and composition of cell-associated HIV DNA population. Both individuals maintained virologic control (<2000 copies/ ml) and presented no evidence of viral evolution or immunologic progression for at
least 2 years after the intersubtype superinfection event. Conclusion: These data revealed that some HIC are able to repeatedly limit replication and evolution of superinfecting viral strains of a different subtype with no signs of disease progression. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Disease progression | pt_BR |
| Subject | HIV controllers | pt_BR |
| Subject | Reservoir | pt_BR |
| Subject | Superinfection | pt_BR |
| Subject | Viral load | pt_BR |
| Embargo date | 2028-08-30 | |
