Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31497
Title: DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016
Authors: Nogueira, Fernanda de Bruycker
Souza, Thiara Manuele Alves
Carneiro, Thaís Chouin
Faria, Nieli Rodrigues da Costa
Santos, Jaqueline Bastos
Torres, Maria Celeste
Ramalho, Izabel Letícia Cavalcante
Aguiar, Shirlei Ferreira de
Nogueira, Rita Maria Ribeiro
Filippis, Ana Maria Bispo de
Santos, Flavia Barreto dos
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Laboratório Central de Saúde Pública do Ceará. Fortaleza, CE, Brasil.
Laboratório Central de Saúde Pública do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
Abstract: In Brazil, DENV-1 introduced in the 80's, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was not fully characterized. In this study, we performed the continuous molecular surveillance after the reemergence period (2012 to 2016), covering the 30 years of circulation of DENV-1 in Brazil. Phylogenetic analysis allowed confirmation of the continued presence of genotype V, as well as three distinct co-circulating lineages. The molecular characterization of the E gene presented two new amino acid substitutions previously unidentified in the country. Phylogeographic analysis has shown that a large flow of migrations has occurred between Brazil and Argentina in the last 10 years.
Keywords: DENV-1 Genotype V
Brazil
Spatiotemporal dispersion pattern
Distinct lineages
keywords: DENV-1 Genótipo V
Padrão de dispersão espaço-temporal
Diversas linhagens
Brasil
Issue Date: 2018
Publisher: Nature Research
Citation: NOGUEIRA, Fernanda de Bruycker et al. DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016. Scientific Reports, v. 8, p. 1-8, Nov. 2018.
DOI: 10.1038/s41598-018-35622-x
ISSN: 2045-2322
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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