Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31497
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dc.contributor.authorNogueira, Fernanda de Bruycker
dc.contributor.authorSouza, Thiara Manuele Alves
dc.contributor.authorCarneiro, Thaís Chouin
dc.contributor.authorFaria, Nieli Rodrigues da Costa
dc.contributor.authorSantos, Jaqueline Bastos
dc.contributor.authorTorres, Maria Celeste
dc.contributor.authorRamalho, Izabel Letícia Cavalcante
dc.contributor.authorAguiar, Shirlei Ferreira de
dc.contributor.authorNogueira, Rita Maria Ribeiro
dc.contributor.authorFilippis, Ana Maria Bispo de
dc.contributor.authorSantos, Flavia Barreto dos
dc.date.accessioned2019-02-08T15:54:49Z
dc.date.available2019-02-08T15:54:49Z
dc.date.issued2018
dc.identifier.citationNOGUEIRA, Fernanda de Bruycker et al. DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016. Scientific Reports, v. 8, p. 1-8, Nov. 2018.
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/31497
dc.language.isoeng
dc.publisherNature Research
dc.rightsopen access
dc.subject.otherDENV-1 Genótipo V
dc.subject.otherPadrão de dispersão espaço-temporal
dc.subject.otherDiversas linhagens
dc.subject.otherBrasil
dc.titleDENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016
dc.typeArticle
dc.identifier.doi10.1038/s41598-018-35622-x
dc.description.abstractenIn Brazil, DENV-1 introduced in the 80's, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was not fully characterized. In this study, we performed the continuous molecular surveillance after the reemergence period (2012 to 2016), covering the 30 years of circulation of DENV-1 in Brazil. Phylogenetic analysis allowed confirmation of the continued presence of genotype V, as well as three distinct co-circulating lineages. The molecular characterization of the E gene presented two new amino acid substitutions previously unidentified in the country. Phylogeographic analysis has shown that a large flow of migrations has occurred between Brazil and Argentina in the last 10 years.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationLaboratório Central de Saúde Pública do Ceará. Fortaleza, CE, Brasil.
dc.creator.affilliationLaboratório Central de Saúde Pública do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
dc.subject.enDENV-1 Genotype V
dc.subject.enBrazil
dc.subject.enSpatiotemporal dispersion pattern
dc.subject.enDistinct lineages
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