Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31575
Title: Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Authors: Barraquer, Isabel Rodriguez
Costa, Federico
Nery Junior, Nivison
Sacramento, Gielson Almeida
Cruz, Jaqueline
Carvalho, Mayara
Olivera, Daiana de
Hagan, José Edward
Wunder Junior, Elsio Augusto
Ribeiro, Guilherme Sousa
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Affilliation: University of California. Department of Medicine. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
Keywords: Dengue
Zika virus
Dengue virus
Zika Virus Infection
Risk Factors
Brazil
Transmission
Epidemic
keywords: Dengue
Zika virus
Vírus da dengue
Infecção pelo virus zika
Fatores de risco
Brasil
Transmissão
Epidemia
Issue Date: 2019
Publisher: American Association for the Advancement of Science
Citation: BARRAQUER, I. R. et al. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science, v. 363, p. 607–610, fev. 2019.
DOI: 10.1126/science.aav6618
ISSN: 0036-8075
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

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