Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31678
Title: Dengue in children: a systematic review of clinical and laboratory factors associated with severity
Authors: Wakimoto, Mayumi Duarte
Camacho, Luiz Antonio Bastos
Guaraldo, Lusiele
Damasceno, Luana Santana
Brasil, Patrícia
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Abstract: Dengue is a potentially life-threatening illness, and children are at higher risk of severity. This review aimed to systematize the identified clinical and laboratory parameters associated with severe dengue in children, as monitoring these signs and fluid-replacement therapy are actually the cornerstones of dengue treatment. Of the 527 studies initially reviewed, 21 were selected as follows: three cohort studies, three case-control studies, 14 cross-sectional studies and one not defined. Eighteen studies were carried out in Asia and three in the Americas. Hepatomegaly, lethargy, abdominal pain, bleeding, hemoconcentration and thrombocytopenia, all referenced as warning signs in the WHO 2009 Guidelines, were the clinical and laboratory parameters independently associated with severity in more than one study. The recognition of these known warning signs associated to severe dengue disease underlines the usefulness of the WHO 2009 classification.
Keywords: Dengue
Severity
Shock syndrome
Systematic review
Children
Issue Date: 2015
Publisher: Taylor & Francis
Citation: WAKIMOTO, Masumi Duarte et al. Dengue in children: a systematic review of clinical and laboratory factors associated with severity. Expert Review of Anti-infective Therapy, v. 13, n. 12, p. 1141-1156, 2015.
DOI: 10.1586/14787210.2015.1100534
ISSN: 1478-7210
Copyright: restricted access
Appears in Collections:ENSP - Artigos de Periódicos
INI - Artigos de Periódicos

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