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2030-01-01
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HUMAN CCR5Δ32 (RS333) POLYMORPHISM HAS NO INFLUENCE ON SEVERITY AND MORTALITY OF INFLUENZA A(H1N1)PDM09 INFECTION IN BRAZILIAN PATIENTS FROM THE POST PANDEMIC PERIOD
Matos, Aline R. et al. | Date Issued: 2019
Author
Matos, Aline R.
Martins, Jéssica S. C. C.
Oliveira, Maria de Lourdes A.
Garcia, Cristiana C.
Siqueira, Marilda Agudo Mendonça Teixeira de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Centro Nacional de Influenza (WHO). Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Centro Nacional de Influenza (WHO). Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Centro Nacional de Influenza (WHO). Rio de Janeiro, RJ, Brasil.
Abstract
Influenza is an acute and highly contagious viral respiratory infection that causes significant morbidity and mortality. The identification of host genetic factors associated with susceptibility and severity of influenza virus infection is of paramount importance. Previous studies evaluating the potential involvement of the CCR5Δ32 polymorphism (rs333), a 32 base pair deletion in CC motif chemokine receptor 5 (CCR5) gene, in severity and mortality of influenza A(H1N1)pdm09 infected individuals have been reported, but their results are quite conflicting.
Keywords in Portuguese
Gripe
Suscetibilidade do hospedeiro
Mortalidade
Gravidade
Brasil
 
Keywords
A(H1N1)Pdm09
CCR5delta32
Host susceptibility
Influenza
Mortality
Severity
Brazil
 
Publisher
Elsevier
Citation
MATOS, Aline R. et al. Human CCR5Δ32 (rs333) polymorphism has no influence on severity and mortality of influenza A(H1N1)pdm09 infection in Brazilian patients from the post pandemic period. Infection, Genetics and Evolution, v. 67, p. 55-59, 2019.
DOI
10.1016/j.meegid.2018.10.024
ISSN
1567-1348