Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31921
Title: Clines in clock genes: fine-tuning circadian rhythms to the environment
Authors: Kyriacou, Charalambos P.
Peixoto, Alexandre A.
Sandrelli, Federica
Costa, Rodolfo
Tauber, Eran
Affilliation: University of Leicester. Department of Genetics. Leicester, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ. Brasil.
University of Padova. Department of Biology. Padova, Italy.
University of Padova. Department of Biology. Padova, Italy.
University of Leicester. Department of Genetics. Leicester, UK.
Abstract: The dissection of the circadian clock into its molecular components represents the most striking and well-studied example of a gene regulatory network underlying a complex behavioural trait. By contrast, the evolutionary analysis of the clock has developed more slowly. Here we review studies that have surveyed intraspecific clock gene variation over large geographical areas and have discovered latitudinal clines in gene frequencies. Such spatial patterns traditionally suggest that natural selection shapes genetic variation, but it is equally possible that population history, or a mixture of demography and selection, could contribute to the clines. We discuss how population genetics, together with functional assays, can illuminate these possible cases of natural selection in Drosophila clock genes.
Keywords: Clock genes
Circadian rhythms
Environment
Clines
Population genetics
Natural selection
keywords: Relógio circadiano
Clines
Genes do relógio
Meio ambiente
Genética populacional
Seleção natural
Issue Date: 2008
Publisher: Elsevier
Citation: KYRIACOU, Charalambos P. et al. Clines in clock genes: fine-tuning circadian rhythms to the environment. Trends in Genetics, v.24, n.3, p.124-132, 2007.
ISSN: 0168-9525
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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