Author | Mottin, Melina | |
Author | Borba, Joyce Villa Verde Bastos | |
Author | Melo Filho, Cleber Camilo | |
Author | Neves, Bruno Junior | |
Author | Muratov, Eugene | |
Author | Torres, Pedro Henrique Monteiro | |
Author | Braga, Rodolpho Campos | |
Author | Perryman, Alexander | |
Author | Ekins, Sean | |
Author | Andrade, Carolina Horta | |
Access date | 2019-02-28T16:19:02Z | |
Available date | 2019-02-28T16:19:02Z | |
Document date | 2018 | |
Citation | MOTTIN, Melina; et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences. v.54, Special, e01002, 10p, 2018. | pt_BR |
ISSN | 1984-8250 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31942 | |
Language | eng | pt_BR |
Publisher | Universidade de São Paulo | pt_BR |
Rights | open access | |
Subject in Portuguese | Zika | pt_BR |
Subject in Portuguese | Flavivírus | pt_BR |
Subject in Portuguese | Antiviral | pt_BR |
Subject in Portuguese | Projeto assistido por computador | pt_BR |
Subject in Portuguese | Triagem virtual | pt_BR |
Subject in Portuguese | Descoberta de drogas | pt_BR |
Title | Computational drug discovery for the Zika virus | pt_BR |
Type | Article | |
DOI | 10.1590/s2175-97902018000001002 | |
Abstract | Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent
epidemics occurred in South America (2014/2015) and expeditiously became a global public health
emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly
spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the
major concern is related to the related severe neurological disorders, especially microcephaly in newborns.
Advances in ZIKV drug discovery have been made recently and constitute promising approaches to
ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their
applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of
computational approaches to ZIKV drug discovery. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil / UniEvangélica. Centro Universitário de Anápolis. Laboratório de Cheminformática. Anápolis, GO, Brasil. | pt_BR |
Affilliation | University of North Carolina. Eshelman School of Pharmacy. Division of Chemical Biology and Medicinal Chemistry. Laboratory for Molecular Modeling. Chapell Hill, NC, USA. / Odessa National Polytechnic University. Department of Checmical Technology. Odessa, Ukraine. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Rutgers University–New Jersey Medical School. Department of Pharmacology, Physiology and Neuroscience. Newark, NJ,, USA. | pt_BR |
Affilliation | Collaborations Pharmaceuticals, Inc. Raleigh, NC, USA. | pt_BR |
Affilliation | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil. | pt_BR |
Subject | Virtual screening | pt_BR |
Subject | Drug discovery | pt_BR |
Subject | Computer-assisted drug design | pt_BR |
Subject | Zika | pt_BR |
Subject | Flavivírus | pt_BR |
Subject | Antiviral | pt_BR |
e-ISSN | 2175-9790 | |