Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32005
Title: Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
Authors: Matos, Denise Cristina Souza
Marcovistz, Rugimar
Silva, Andréa Marques Vieira da
Quintilio, Wagner
Georgini, Ricardo Amaral
Affilliation: Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Abstract: The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.
keywords: DTP vaccine
Pertussis whole cell
Enzyme-linked immunosorbent assay
Intracerebral mouse protection test
Issue Date: 2012
Citation: MATOS, Denise Cristina Souza et al. Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine. Braz. J. Microbiol., São Paulo , v. 43, n. 2, p. 429-431, 2012.
DOI: 10.1590/S1517-83822012000200001
ISSN: 1678-4405
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos

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