Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/32090
Type
ArticleCopyright
Restricted access
Embargo date
2022-01-01
Collections
- IOC - Artigos de Periódicos [12488]
Metadata
Show full item record
TRYPANOSOMA CRUZI ALTERS ADHERENS JUNCTIONS IN CARDIOMYOCYTES
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ. Brasil.
Abstract
We analyzed the distribution and expression of cadherin and b-catenin during Trypanosoma cruziecardiomyocyte interaction. Confocal
microscopy revealed cadherin associated with b-catenin at the cellecell contacts. After 24 h of infection, the spatial distribution and expression
of both adherens junction (AJ) proteins remained unaltered. In contrast, loss of N-cadherinecatenin complex was visualized in highly infected
cardiomyocytes. Immunoblotting assays corroborated the spatial disorder, showing a 46% reduction in both N-cadherin and b-catenin expression
at later infection (72 h of infection). Our data demonstrate that T. cruzi infection disturbs AJs, which can result in loss of cardiac tension and may
contribute to the cardiac dysfunctions present in T. cruzi infection.
Share