Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32288
Title: Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness.
Authors: Falcoff, R
Barral Netto, Manoel
Stiffels, C
Bouthilliers, Y
Barral, Aldina Maria Prado
Freitas, Luiz Antonio Rodrigues de
Mevels, J. C
Moutons, D
Affilliation: INSERM. Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Abstract: The degree of resistance to a local Leishmania amazonensis challenge has been compared in lines of mice obtained by selective breeding for high or low immunoresponsiveness: High and Low antibody responder mice of Selections I and I1 (HI, HI, and L1, Lll lines) and high and low responder mice to T mitogen PHA (Hi/PHA and Lo/PHA). The aim of this preliminary study was to focus attention on genetic differences related with well defined immune characteristics. Clear-cut results were obtained, both Hi and HII mice developed large and disseminating lesions, the rate of symptom aggravation being faster in HI^, while L1 and LI1 proved resistant to parasites, only small and transient lesions being observed for them during a 150 days follow up. The outcome of infection also differs in Hi/PHA and Lo/PHA mice, Hi/PHA having a resistant and Lo/PHA a susceptible phenotype.
Keywords: Leishmania amazonensis
Genetics of resistance
High and Low immunoresponsiveness
Mice
Leishmania
keywords: Leishmania amazonensis
Genética de resistência
Alta e baixa imunorresponsividade
Camundongos
Leishmania
Issue Date: 1991
Publisher: Wiley
Citation: FALCOFF, R. et al. Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness. Parasite Immunology, v. 13, p. 639-647, 1991.
Description: Barral Netto, M.; Barral, A. M. P.; Freitas, Luiz Antônio Rodrigues de. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 0141-9838
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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