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VARIATIONS IN SUSCEPTIBILITY TO LEISHMANIA AMAZONENSIS INFECTION IN LINES OF MICE SELECTED FOR HIGH OR LOW IMMUNORESPONSIVENESS.
Genética de resistência
Alta e baixa imunorresponsividade
Camundongos
Leishmania
Genetics of resistance
High and Low immunoresponsiveness
Mice
Leishmania
Author
Affilliation
INSERM. Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil.
Institut Curie. Section de Biologie. Paris, France.
Institut Curie. Section de Biologie. Paris, France.
Abstract
The degree of resistance to a local Leishmania amazonensis challenge
has been compared in lines of mice obtained by selective breeding for high or low
immunoresponsiveness: High and Low antibody responder mice of Selections I
and I1 (HI, HI, and L1, Lll lines) and high and low responder mice to T mitogen
PHA (Hi/PHA and Lo/PHA). The aim of this preliminary study was to focus
attention on genetic differences related with well defined immune characteristics.
Clear-cut results were obtained, both Hi and HII mice developed large and
disseminating lesions, the rate of symptom aggravation being faster in HI^, while
L1 and LI1 proved resistant to parasites, only small and transient lesions being
observed for them during a 150 days follow up. The outcome of infection also
differs in Hi/PHA and Lo/PHA mice, Hi/PHA having a resistant and Lo/PHA a
susceptible phenotype.
Keywords in Portuguese
Leishmania amazonensisGenética de resistência
Alta e baixa imunorresponsividade
Camundongos
Leishmania
Keywords
Leishmania amazonensisGenetics of resistance
High and Low immunoresponsiveness
Mice
Leishmania
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