Author | Girianelli, Vania Reis | |
Author | Thuler, Luiz Claudio Santos | |
Author | Silva, Gulnar Azevedo e | |
Access date | 2019-04-03T21:19:10Z | |
Available date | 2019-04-03T21:19:10Z | |
Document date | 2016 | |
Citation | GIRIANELLI, Vania Reis; THULER, Luiz Claudio Santos; SILVA, Gulnar Azevedo e. Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 3, p. 147-153, 2016. | pt_BR |
ISSN | 0100-7203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32349 | |
Language | eng | pt_BR |
Publisher | Thieme Open | pt_BR |
Rights | open access | pt_BR |
Title | Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up | pt_BR |
Type | Article | pt_BR |
DOI | 10.1055/s-0036-1580712 | |
Abstract | Purpose: To compare the predictive capability of HPV and Pap smear tests for screening pre-cancerous lesions of the cervix over a three-year follow-up, in a population of users of the Brazilian National Health System (SUS). Methods: This is a retrospective cohort study of 2,032 women with satisfactory results for Pap smear and HPV tests using second-generation hybrid capture, made in a previous study. We followed them for 36 months with data obtained from medical records, the Cervix Cancer Information System (SISCOLO), and the Mortality Information System (SIM). The outcome was a histological diagnosis of cervical intraepithelial neoplasia grade 2 or more advanced lesions (CIN2þ). We constructed progression curves of the baseline test results for the period, using the Kaplan-Meier method, and estimated sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratios for each test. Results: A total of 1,440 women had at least one test during follow-up. Progression curves of the baseline test results indicated differences in capability to detect CIN2þ (p < 0.001) with significantly greater capability when both tests were abnormal, followed by only a positive HPV test. The HPV test was more sensitive than the Pap smear (88.7% and 73.6%, respectively; p < 0.05) and had a better negative likelihood ratio (0.13 and 0.30, respectively). Specificity and positive likelihood ratio of the tests were similar. Conclusions: These findings corroborate the importance of HPV test as a primary cervical cancer screening. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Division of Clinical Research. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Uterine cervical neoplasm | pt_BR |
Subject | Prevention and control | pt_BR |
Subject | Mass screening | pt_BR |
Subject | Papanicolaou | pt_BR |
Subject | HPV | pt_BR |
Subject | Cohort study | pt_BR |
e-ISSN | 0100-7203 | |