Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32443
Title: Taliglucerase alfa in Gaucher disease: Description of a Brazilian experience
Authors: Cravo, Renata
Rotman, Vivian
Oliveira, Patricia Mouta
Defendi, Hugo
Conceição, D. Araujo
Xavier, Janaina Xavier
Chertkoff, Raul
Noronha, Tatiana Guimarães
Maia, Maria De Lourdes Sousa
Affilliation: Hemorio Hospital. Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Protalix Biotherapeutics. Carmiel, Israel.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Abstract: We evaluated retrospectively, efficacy and safety of taliglucerase alfa for Gaucher disease in a Brazilian population. Thirteen patients were included for efficacy analysis only one of them naïve to enzyme replacement therapy. All the parameters evaluated remained stable throughout treatment (mean duration 3,5 years). Only three patients (out of 35) had to discontinue treatment due to a serious adverse event. In conclusion, treatment with taliglucerase alfa was found to be safe and efficient.
Keywords: Gaucher disease
Lysosomal storage diseases
Enzyme replacement therapy
Taliglucerase alfa
Imiglucerase
Velaglucerase
Issue Date: 2018
Citation: CRAVO, Renata et al. Taliglucerase alfa in Gaucher disease: Description of a Brazilian experience. Blood Cells, Molecules & Diseases, La Jolla, v. 68, p. 160-162, 2018.
DOI: 10.1016/j.bcmd.2017.01.005
ISSN: 1096-0961
Copyright: restricted access
Appears in Collections:Biomanguinhos - Artigos de Periódicos

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