Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32501
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dc.contributor.authorAmorim, Camila F
dc.contributor.authorCarvalho, Natália Barbosa
dc.contributor.authorAbraão Neto, José
dc.contributor.authorSantos, Silvane Maria Braga
dc.contributor.authorGrassi, Maria Fernanda Rios
dc.contributor.authorCarvalho, Lucas Pedreira de
dc.contributor.authorCarvalho, Edgar Marcelino de
dc.date.accessioned2019-04-15T18:37:09Z
dc.date.available2019-04-15T18:37:09Z
dc.date.issued2019
dc.identifier.citationAMOARIM, C. F. et al. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research, p. 1-10, 2019.
dc.identifier.issn2314-8861
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/32501
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais, which is financed by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) from Ministério da Ciência, Tecnologia, Inovações e Comunicações (grant number 465229/2014-0).
dc.language.isoeng
dc.publisherHindwai
dc.rightsopen access
dc.subject.otherHTLV-1
dc.subject.otherVírus Linfotrópico T Humano 1
dc.subject.otherCélulas NK
dc.subject.otherInfecção
dc.subject.otherHumanos
dc.titleThe Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
dc.typeArticle
dc.identifier.doi10.1155/2019/6574828
dc.description.abstractenThe cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1). As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes. NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection. The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP. The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot. Phenotypic characterization of NK cells was performed by flow cytometry. The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients. The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients. HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC. These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.
dc.subject.enHTLV-1
dc.subject.enHuman T-lymphotropic virus 1
dc.subject.enKiller Cells, Natural
dc.subject.enInfection
dc.subject.enHumans
Appears in Collections:BA - IGM - Artigos de Periódicos

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