Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32521
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dc.contributor.authorBeck, Lílian
dc.contributor.authorVan-Lüme, Danielle S. M.
dc.contributor.authorSouza, Joelma R.
dc.contributor.authorDomingues, Ana L. C.
dc.contributor.authorFavre, Tereza
dc.contributor.authorAbath, Frederico G. C.
dc.contributor.authorMontenegro, Silvia L. M.
dc.date.accessioned2019-04-16T15:34:19Z
dc.date.available2019-04-16T15:34:19Z
dc.date.issued2008
dc.identifier.citationBECK, Lilian et al. Discriminating acute from chronic human schistosomiasis mansoni. Acta Tropica, v. 108, p. 229–233, 2008.
dc.identifier.issn0001-706X
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/32521
dc.language.isoeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subject.otherDiagnóstico Diferencial
dc.subject.otherSchistosoma mansoni
dc.subject.otherCaracterísticas operacionais do receptor
dc.subject.otherEsquistossomose aguda
dc.subject.otherEsquistossomose crônica
dc.titleDiscriminating acute from chronic human schistosomiasis mansoni
dc.typeArticle
dc.identifier.doi10.1016/j.actatropica.2008.08.012
dc.description.abstractenSpecific immunoglobulin (IgA, IgG and IgM) responses to different antigen targets (soluble eggs antigen – SEA, soluble worm adult protein – SWAP and keyhole limpet hole – KLH) were measured by enzyme linked immunosorbent assay (ELISA) in patients with acute and chronic schistosomiasis, aswell as patients without schistosomiasis. SEA IgA and KLH IgM presented high discriminatory powers to distinguish acute from chronic schistosomiasis, with calculated areas under the curve (AUCs) of 0.88 and 0.82, respectively, obtained from receiver operating characteristic (ROC) curve. On the other hand, these tests, particularly SEA IgA were not useful to distinguish schistosomiasis (including the acute and chronic forms) from individuals without this disease, but infected with other intestinal parasites (Ascaris lumbricoides, Trichuris trichiura and hookworm). By contrast, SWAP IgG and SEA IgG were able to discriminate schistosomiasis patients from healthy individuals and patients infected with other parasites (AUCs of 0.96 and 0.85, respectively). Thus, it is possible to use a combination of serological tests, such as SEA IgA and SWAP IgG, to simultaneously establish the diagnosis of schistosomiasis and discriminate the acute from the chronic forms of the disease.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
dc.creator.affilliationUniversidade Federal de Pernambuco. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
dc.subject.enDifferential diagnosis
dc.subject.enSchistosoma mansoni
dc.subject.enReceiver operating characteristic
dc.subject.enAcute schistosomiasis
dc.subject.enChronic schistosomiasis
dc.identifier.eissn1873-6254
Appears in Collections:PE - IAM - Artigos de Periódicos
IOC - Artigos de Periódicos

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