Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32538
Title: Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil
Authors: Fernandes, Alexandre
Iñiguez, Alena M.
Lima, Valdirene S.
Souza, Sheila M. F. Mendonça de
Ferreira, Luiz Fernando
Vicente, Ana Carolina P.
Jansen, Ana Maria
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Paleoparasitologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
Abstract: We evaluated the presence and distribution of Trypanosoma cruzi DNA in a mummy presenting with megacolon that was dated as approximately 560 ± 40 years old. The mummy was from the Peruaçu Valley in the state of Minas Gerais, Brazil. All samples were positive for T. cruzi minicircle DNA, demonstrating the presence and broad dissemination of the parasite in this body. From one sample, a mini-exon gene fragment was recovered and characterized by sequencing and was found to belong to the T. cruzi I genotype. This finding suggests that T. cruzi I infected humans during the pre-Columbian times and that, in addition to T. cruzi infection, Chagas disease in Brazil most likely preceded European colonization.
Keywords: Brazilian mummy
Chagas disease
Ancient DNA
Trypanosoma cruzi
Megacolon
keywords: Trypanosoma cruzi I
Doença de Chagas
Múmias brasileiras
DNA Antigo
Megacolo
Minas Gerais
DeCS: Megacolo
Issue Date: 2008
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: FERNANDES, Alexandre et al. Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil. Memórias do Instituto Oswaldo Cruz, v. 103, n. 5, p. 514-516, Aug. 2008.
DOI: 10.1590/S0074-02762008000500021
ISSN: 0074-0276
Copyright: open access
Appears in Collections:ENSP - Artigos de Periódicos
IOC - Artigos de Periódicos

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