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https://www.arca.fiocruz.br/handle/icict/32538| Title: | Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil |
| Authors: | Fernandes, Alexandre Iñiguez, Alena M. Lima, Valdirene S. Souza, Sheila M. F. Mendonça de Ferreira, Luiz Fernando Vicente, Ana Carolina P. Jansen, Ana Maria |
| Affilliation: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Paleoparasitologia. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. |
| Abstract: | We evaluated the presence and distribution of Trypanosoma cruzi DNA in a mummy presenting with megacolon that was dated as approximately 560 ± 40 years old. The mummy was from the Peruaçu Valley in the state of Minas Gerais, Brazil. All samples were positive for T. cruzi minicircle DNA, demonstrating the presence and broad dissemination of the parasite in this body. From one sample, a mini-exon gene fragment was recovered and characterized by sequencing and was found to belong to the T. cruzi I genotype. This finding suggests that T. cruzi I infected humans during the pre-Columbian times and that, in addition to T. cruzi infection, Chagas disease in Brazil most likely preceded European colonization. |
| Keywords: | Brazilian mummy Chagas disease Ancient DNA Trypanosoma cruzi Megacolon |
| keywords: | Trypanosoma cruzi I Doença de Chagas Múmias brasileiras DNA Antigo Megacolo Minas Gerais |
| DeCS: | Megacolo |
| Issue Date: | 2008 |
| Publisher: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
| Citation: | FERNANDES, Alexandre et al. Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil. Memórias do Instituto Oswaldo Cruz, v. 103, n. 5, p. 514-516, Aug. 2008. |
| DOI: | 10.1590/S0074-02762008000500021 |
| ISSN: | 0074-0276 |
| Copyright: | open access |
| Appears in Collections: | ENSP - Artigos de Periódicos IOC - Artigos de Periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| AlexandreFernandez_AlenaIniguez_etal_IOC_2008.pdf | 351.66 kB | Adobe PDF | View/Open |
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