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dc.contributor.authorBarcelos, Amanda
dc.contributor.authorTibirica, Eduardo
dc.contributor.authorLamas, Cristiane
dc.identifier.citationBARCELOS, Amanda; TIBIRICA, Eduardo; LAMAS, Cristiane. Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy. Microvascular Research, v. 118, p. 61-68, 2018.
dc.rightsopen access
dc.titleEvaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
dc.description.abstractenObjective: To evaluate the systemic microcirculation of patients with infective endocarditis (IE). Methods: This is a comparative study of patients with definite IE by the modified Duke criteria admitted to our center for treatment. A reference group of sex- and age-matched healthy volunteers was included. Microvascular flow was evaluated in the forearm using a laser speckle contrast imaging system, for noninvasive measurement of cutaneous microvascular perfusion, in combination with skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to test microvascular reactivity. Microvascular density was evaluated using skin video-ca-pillaroscopy. Results: We studied 22 patients with IE; 15 were male and seven female. The mean age and standard deviation(SD) were 45.5 ± 17.3 years. Basal skin microvascular conductance was significantly increased in patients with IE, compared with healthy individuals (0.36 ± 0.13 versus 0.21 ± 0.08 APU/mmHg;P< 0.0001). The in-crease in microvascular conductance induced by ACh in patients was 0.21 ± 0.17 and in the reference group, it was 0.37 ± 0.14 APU/mmHg (P= 0.0012). The increase in microvascular conductance induced by SNP inpatients was 0.18 ± 0.14 and it was 0.29 ± 0.15 APU/mmHg (P= 0.0140) in the reference group. The basal mean skin capillary density of patients (135 ± 24 capillaries/mm2) was significantly higher, compared with controls (97 ± 21 capillaries/mm2;P< 0.0001).Conclusions: The main findings in the microcirculation of patients with IE were greater basal vasodilation and areduction of the endothelium-dependent and -independent microvascular reactivity, as well as greater functionalskin capillary density compared to healthy individuals.
dc.creator.affilliationMinistry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil.
dc.creator.affilliationMinistry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationMinistry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Duque de Caxias, RJ, Brasil.
dc.subject.enInfective endocarditis
dc.subject.enMicrovascular dysfunction
dc.subject.enCapillary density
dc.subject.enSpeckle contrast imaging
dc.subject.enSkin video-capillaroscopy
Appears in Collections:INI - Artigos de Periódicos
IOC - Artigos de Periódicos
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