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SCHISTOSOMA MANSONI VENOM ALLERGEN-LIKE PROTEINS: PHYLOGENETIC RELATIONSHIPS, STAGE-SPECIFIC TRANSCRIPTION AND TISSUE LOCALIZATION AS PREDICTORS OF IMMUNOLOGICAL CROSS-REACTIVITY
Farias, Leonardo Paiva et al. | Date Issued: 2019
Author
Farias, Leonardo Paiva
Chalmers, Iain W.
Perally, Samirah
Rofatto, Henrique K.
Jackson, Colin J.
Brown, Martha
Khouri, Mariana I.
Barbosa, Mayra M. F.
Hensbergen, Paul J.
Hokke, Cornelis H.
Leite, Luciana C. C.
Hoffmann, Karl F.
Affilliation
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Universidade de São Paulo. Pós-Graduação Interunidades em Biotecnologia. São Paulo, SP, Brasil.
Leiden University Medical Centre. Center for Proteomics and Metabolomics. RC Leiden, The Netherlands.
Leiden University Medical Centre. Department of Parasitology. RC Leiden, The Netherlands.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Abstract
Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.
Keywords in Portuguese
Veneno alérgeno-like
Reatividade cruzada imunológica
Localização de tecido
Schistosoma mansoni
 
Keywords
Venom allergen-like
Immunological cross reactivity
Tissue localization
Schistosoma mansoni
 
Publisher
Elsevier
Citation
FARIAS, Leonardo Paiva et. al. Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity. International Journal for Parasitology, v. 49, p. 593–599, 2019.
DOI
10.1016/j.ijpara.2019.03.003
ISSN
0020-7519
Notes
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