Author | Santana, Claudia de Carvalho | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Oliveira, Geraldo Gileno de Sá | |
Author | dosSantos, Washington Luis Conrado | |
Access date | 2019-07-16T14:04:38Z | |
Available date | 2019-07-16T14:04:38Z | |
Document date | 2019 | |
Citation | SANTANA, Claudia de Carvalho. Disorganization of spleen compartments and dermatitis in canine visceral leishmaniasis. Surgical and Experimental Pathology, p. 1-8, 2019. | pt_BR |
ISSN | 2520-8454 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34146 | |
Sponsorship | FAPESB (grant no. APR0434/2005) and
Fundação OswaldoCruz (Fiocruz. http://portal.fiocruz.br/pt-br)-CNPq PROEP
grant 400905/2013–2. WLCS received a scholarship from CNPq (http://www.
cnpq.br/). | pt_BR |
Language | eng | pt_BR |
Publisher | BMC | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania chagasi | pt_BR |
Subject in Portuguese | Leishmaniose visceral canina | pt_BR |
Subject in Portuguese | Baço | pt_BR |
Subject in Portuguese | Dermatite | pt_BR |
Subject in Portuguese | Cão | pt_BR |
Subject in Portuguese | Teste cutâneo de leishmanina | pt_BR |
Title | Disorganization of spleen compartments and dermatitis in canine visceral leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s42047-019-0040-0 | pt_BR |
Abstract | The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | Leishmania chagasi | pt_BR |
Subject | Canine visceral leishmaniasis | pt_BR |
Subject | Spleen | pt_BR |
Subject | Dermatitis | pt_BR |
Subject | Dog | pt_BR |
Subject | Leishmanin skin test | pt_BR |