Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/35178
Title: Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals
Authors: Villar, Livia Melo
Geloneze, Bruno
Vasques, Ana Carolina Junqueira
Pires, Maria Lucia Elias
Miguel, Juliana Custódio
Silva, Elisangela Ferreira da
Marques, Vanessa Alves
Scalioni, Leticia de Paula
Lampe, Elisabeth
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Universidade de Campinas. Gastrocentro. Laboratório de Investigação em Metabolismo e Diabetes. Campinas, SP, Brasil.
Universidade de Campinas. Gastrocentro. Laboratório de Investigação em Metabolismo e Diabetes. Campinas, SP, Brasil / Universidade de Campinas. Escola de Ciências Aplicadas. Campinas, SP, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Escola de Medicina. Departamento de Medicina Clínica de Cirurgia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Abstract: Diabetes mellitus type 2 (DM2) patients have higher risk to be infected with parenterally transmitted viruses, like hepatitis B or C virus. This study aims to determine HBV and HCV infection prevalence in DM2 patients from Northeast and Southeast Brazil. A total of 537 DM2 patients were included, 194 (36.12%) males and 343 (63.87%) females, with mean age of 57.13±11.49 years. HBV and HCV markers were determined using serological and molecular analysis, and risk factors were evaluated in a subgroup from Southeast (n = 84). Two HBV acute (HBsAg+/anti-HBc -) and one HBV chronic case (HBsAg+/anti-HBc+) were found. Six individuals (1.1%) were isolated anti-HBc, 37 (6.9%) had HBV infection resolved (anti-HBc+/anti-HBs+), 40 (7.4%) were considered HBV vaccinated (anti-HBc-/anti-HBs+). Thirteen patients (2.42%) had anti-HCV and 7 of them were HCV RNA+. In the subgroup, anti-HBc positivity was associated to age and anti-HCV positivity was associated to age, time of diabetes diagnosis, total bilirubin, indirect bilirubin, alkaline phosphatase at bivariate analysis, but none of them was statistically significant at multivariate analysis. As conclusion, low prevalence of HBV and high prevalence HCV was found in DM2 patients.
Keywords: Hepatitis B
Hepatitis C
Diabetes Millitus type 2
Prevalence
keywords: Hepatite B
Hepatite C
Diabetes mellitus tipo 2
Prevalência
Issue Date: 2019
Publisher: Public Library of Science
Citation: VILLAR, Livia Melo et al. Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals. Plos One, v. 14, n. 2, p. 1-10, Feb. 2019.
DOI: 10.1371/journal.pone.0211193
ISSN: 1932-6203
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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