Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/35595
Title: Cardiomyogenesis modeling using pluripotent stem cells: the role of microenvironmental signaling
Authors: Leitolis, Amanda
Robert, Anny Waloski
Pereira, Isabela Tiemy
Dominguez, Alejandro Correa
Stimamiglio, Marco Augusto
Affilliation: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
Abstract: Pluripotent stem cells (PSC) can be used as a model to study cardiomyogenic differentiation. In vitro modeling can reproduce cardiac development through modulation of some key signaling pathways. Therefore, many studies make use of this strategy to better understand cardiomyogenesis complexity and to determine possible ways to modulate cell fate. However, challenges remain regarding efficiency of differentiation protocols, cardiomyocyte (CM) maturation and therapeutic applications. Considering that the extracellular milieu is crucial for cellular behavior control, cardiac niche studies, such as those identifying secreted molecules from adult or neonatal tissues, allow the identification of extracellular factors that may contribute to CM differentiation and maturation. This review will focus on cardiomyogenesis modeling using PSC and the elements involved in cardiac microenvironmental signaling (the secretome – extracellular vesicles, extracellular matrix and soluble factors) that may contribute to CM specification and maturation.
Keywords: Myocytes
Cardiac
Pluripotent Stem Cells
Cell Differentiation
Extracellular Vesicles
Keywords in spanish: Miocitos Cardíacos
Células Madre Pluripotentes
Diferenciación Celular
keywords: Maturação de cardiomiócitos
DeCS: Miócitos Cardíacos
Células-Tronco Pluripotentes
Diferenciação Celular
Vesículas Extracelulares
Issue Date: 2019
Publisher: Frontiers Media
Citation: LEITOLIS, Amanda et al. Cardiomyogenesis modeling using pluripotent stem cells: the role of microenvironmental signaling. Frontiers in Cell and Developmental Biology, v. 7, n. 164, p. 1–20, 2019.
DOI: 10.3389/fcell.2019.00164
ISSN: 2296-634X
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos

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