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2025-01-01
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- INI - Artigos de Periódicos [3186]
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ANTIRETROVIRAL THERAPY AND VAGINALLY ADMINISTERED CONTRACEPTIVE HORMONES: A THREE-ARM, PHARMACOKINETIC STUDY
AIDS
Intravaginal rings
Women with HIV
Efavirenz
Atazanavir
Etonogestrel
Ethinylestradiol
Author
Scarsi, Kimberly K
Cramer, Yoninah S
Rosenkranz, Susan L
Aweeka, Francesca
Berzins, Baiba
Coombs, Robert W
Coughlin, Kristine
Moran, Laura E
Zorrilla, Carmen D
Akelo, Victor
Aziz, Mariam
Friedman, Ruth K
Gingrich, David
Swaminathan, Shobha
Godfrey, Catherine
Cohn, Susan E
AIDS Clinical Trials Group A5316 Study Team
Cramer, Yoninah S
Rosenkranz, Susan L
Aweeka, Francesca
Berzins, Baiba
Coombs, Robert W
Coughlin, Kristine
Moran, Laura E
Zorrilla, Carmen D
Akelo, Victor
Aziz, Mariam
Friedman, Ruth K
Gingrich, David
Swaminathan, Shobha
Godfrey, Catherine
Cohn, Susan E
AIDS Clinical Trials Group A5316 Study Team
Affilliation
University of Nebraska Medical Center, Department of Pharmacy Practice and Science, Omaha, NE, USA.
Harvard T H Chan School of Public Health, Boston, MA, USA; Frontier Science Foundation, Brookline, MA, USA.
Harvard T H Chan School of Public Health, Boston, MA, USA; Frontier Science Foundation, Brookline, MA, USA.
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.
Division of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Department of Medicine and Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Frontier Science & Technology Research Foundation, Amherst, NY, USA.
Social & Scientific Systems, Silver Spring, MD, USA.
University of Puerto Rico School of Medicine, Obstetrics and Gynecology Department, San Juan, Puerto Rico.
Kenya Medical Research Institute, Kisumu, Kenya.
Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.
Division of Infectious Diseases, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Division of AIDS, National Institutions of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Division of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Harvard T H Chan School of Public Health, Boston, MA, USA; Frontier Science Foundation, Brookline, MA, USA.
Harvard T H Chan School of Public Health, Boston, MA, USA; Frontier Science Foundation, Brookline, MA, USA.
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.
Division of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Department of Medicine and Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Frontier Science & Technology Research Foundation, Amherst, NY, USA.
Social & Scientific Systems, Silver Spring, MD, USA.
University of Puerto Rico School of Medicine, Obstetrics and Gynecology Department, San Juan, Puerto Rico.
Kenya Medical Research Institute, Kisumu, Kenya.
Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.
Division of Infectious Diseases, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Division of AIDS, National Institutions of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Division of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Abstract
Drug-drug interactions between orally administered antiretroviral therapy (ART) and hormones released from an intravaginal ring are not known. We hypothesised that ART containing either efavirenz or ritonavir-boosted atazanavir would alter plasma concentrations of vaginally administered etonogestrel and ethinylestradiol but that ART concentrations would be unchanged during use of an intravaginal ring.
Keywords
Antiretroviral therapy (ART)AIDS
Intravaginal rings
Women with HIV
Efavirenz
Atazanavir
Etonogestrel
Ethinylestradiol
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